DIABLO anticorps

N° du produit ABIN371649

Détail du produit anti-DIABLO anticorps

Antigène: DIABLO (Second Mitochondria-Derived Activator of Caspase (DIABLO))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp DIABLO est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificité: This antibody is specific for Human SMAC/DIABLO.

Attributs du produit: Synonyms: Diablo homolog mitochondrial, Second mitochondria-derived activator of caspase, DirectIAP-binding protein with low pI

Purification: Purified

Clone: 2D12

Isotype: IgG2b

Information d'application

Indications d'application: ELISA: 1/1,000-1/2,000. Western Blot: 1/5,000-1/10,000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: 100 mM Borate buffered saline, pH 8.2. No preservatives or amine-containing buffer salts added.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Date de péremption: 12 months

Détails sur DIABLO

Antigène: DIABLO (Second Mitochondria-Derived Activator of Caspase (DIABLO))

Autre désignation: DIABLO / SMAC (DIABLO Produits)

Synonymes: anticorps smac, anticorps smac3, anticorps diablo-s, anticorps 0610041G12Rik, anticorps 1700006L01Rik, anticorps AU040403, anticorps Smac, anticorps DFNA64, anticorps SMAC, anticorps DBO, anticorps XSmac, anticorps diablo, IAP-binding mitochondrial protein, anticorps diablo IAP-binding mitochondrial protein, anticorps diablo, IAP-binding mitochondrial protein L homeolog, anticorps diablo, anticorps Diablo, anticorps DIABLO, anticorps diablo.L

Sujet: SMAC/DIABLO (second mitochondria-derived activator of caspase/direct IAP-binding protein with low PI) is a mitochondrial protein that functions as a regulatory component during apoptosis. It is encoded by a nuclear gene and is subsequently imported into the mitochondria where the N-terminus is removed generating the mature form of the molecule. SMAC/DIABLO has been shown to neutralize the antiapoptotic effect of the inhibitor of apoptosis protein (IAP) family, a major group of apoptosis regulators that have been shown to directly block caspase activity thereby blocking apoptosis. (Ref.1-6)Synonyms: Diablo homolog mitochondrial, Direct IAP-binding protein with low pI, Second mitochondria-derived activator of caspase

ID gène: 56616

UniProt: Q9NR28

Pathways: Apoptose, Caspase Cascade in Apoptosis, Positive Regulation of Endopeptidase Activity