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GRIN2B anticorps (pTyr1252)

GRIN2B Reactivité: Humain, Rat, Souris, Chien, Boeuf (Vache), Poulet, Poisson zèbre (Danio rerio), Non-Human Primate WB, IF, IHC (fro) Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN372685
  • Antigène Voir toutes GRIN2B Anticorps
    GRIN2B (Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2B (GRIN2B))
    Épitope
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    pTyr1252
    Reactivité
    • 196
    • 182
    • 153
    • 29
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    • 3
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    Humain, Rat, Souris, Chien, Boeuf (Vache), Poulet, Poisson zèbre (Danio rerio), Non-Human Primate
    Hôte
    • 204
    • 40
    • 1
    Lapin
    Clonalité
    • 206
    • 39
    Polyclonal
    Conjugué
    • 108
    • 11
    • 9
    • 9
    • 9
    • 9
    • 9
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    • 1
    Cet anticorp GRIN2B est non-conjugé
    Application
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    Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Specificité
    This antibody recognizes the ~180k NMDAR NR2B subunit protein phosphorylated at Tyr1252. Immunolabeling of the NMDA NR2B subunit band is blocked by the phosphopeptide used as the antigen but not by the corresponding dephosphopeptide. Immunolabeling is also blocked by lambda-phosphatase treatment. The antibody may also show some slight reactivity with Tyr1246 of NR2A.
    Réactivité croisée (Details)
    Species reactivity (expected):Bovine, Canine, Chicken, Human, Mouse, Zebrafish and non-Human Primates.
    Species reactivity (tested):Rat.
    Purification
    Sequential Chromatography on phospho- and dephosphopeptide affinity columns.
    Immunogène
    Phosphopeptide corresponding to amino acid residues surrounding the phospho-Tyr1252 of the NR2B subunit of the rat NMDA receptor.
    Isotype
    IgG
    Top Product
    Discover our top product GRIN2B Anticorps primaire
  • Indications d'application
    Western blot: 1/1000. Immunohistochemistry: 1/400.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg/mL BSA and 50 % Glycerol.
    Conseil sur la manipulation
    Avoid repeated freezing and thawing.
    Stock
    -20 °C
    Stockage commentaire
    Store the antibody undiluted (in aliquots) at-20 °C.
  • Antigène
    GRIN2B (Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2B (GRIN2B))
    Autre désignation
    NMDAR2B (GRIN2B Produits)
    Synonymes
    anticorps NMDAR2B, anticorps GluN2B, anticorps MRD6, anticorps NR2B, anticorps hNR3, anticorps nmdar2b, anticorps nr2b, anticorps AW490526, anticorps Nmdar2b, anticorps glutamate ionotropic receptor NMDA type subunit 2B, anticorps glutamate receptor, ionotropic, N-methyl D-aspartate 2B L homeolog, anticorps glutamate receptor, ionotropic, NMDA2B (epsilon 2), anticorps GRIN2B, anticorps Grin2b, anticorps grin2b.L
    Sujet
    The NMDA receptor (NMDAR) plays an essential role in memory, neuronal development and it has also been implicated in several disorders of the central nervous system including Alzheimer's, epilepsy and ischemic neuronal cell death (Grosshans et al., 2002, Wenthold et al., 2003, Carroll and Zukin, 2002). The rat NMDAR1 (NR1) was the first subunit of the NMDAR to be cloned. The NR1 protein can form NMDA activated channels when expressed in Xenopus oocytes but the currents in such channels are much smaller than those seen in situ. Channels with more physiological characteristics are produced when the NR1 subunit is combined with one or more of the NMDAR2 (NR2 A-D) subunits (Ishii et al., 1993). Phosphorylation of Tyr1252 is thought to potentiate NMDA receptor-dependent influx of calcium (Takasu et al., 2002).Synonyms: GRIN2B, Glutamate [NMDA] receptor subunit epsilon-2, N-methyl D-aspartate receptor subtype 2B, N-methyl-D-aspartate receptor subunit 3, NMDA Receptor 2B
    ID gène
    2904
    NCBI Accession
    NP_000825
    UniProt
    Q13224
    Pathways
    Response to Growth Hormone Stimulus, Synaptic Membrane, Feeding Behaviour, Regulation of long-term Neuronal Synaptic Plasticity
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