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GRIN2B anticorps (pTyr1472)

GRIN2B Reactivité: Humain, Rat, Souris, Chien, Boeuf (Vache), Poulet, Poisson zèbre (Danio rerio), Non-Human Primate WB Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN372687
  • Antigène Voir toutes GRIN2B Anticorps
    GRIN2B (Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2B (GRIN2B))
    Épitope
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    pTyr1472
    Reactivité
    • 196
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    • 153
    • 29
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    • 3
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    Humain, Rat, Souris, Chien, Boeuf (Vache), Poulet, Poisson zèbre (Danio rerio), Non-Human Primate
    Hôte
    • 204
    • 40
    • 1
    Lapin
    Clonalité
    • 206
    • 39
    Polyclonal
    Conjugué
    • 108
    • 11
    • 9
    • 9
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    • 9
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    • 2
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    • 2
    • 2
    • 1
    Cet anticorp GRIN2B est non-conjugé
    Application
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    Western Blotting (WB)
    Specificité
    This antibody is specific for the ~180k NMDAR NR2B-subunit protein phosphorylated at Tyr1472 in Western blots. The antibody also labels proteins of ~65k and ~115k. Immunolabeling is completely blocked by blocked by either lambda-Ptase or by the phosphopeptide used as the antigen but not by the corresponding dephosphopeptide.
    Réactivité croisée (Details)
    Species reactivity (expected):Bovine, Canine, Chicken, Human, Mouse, non-Human Primates and Zebrafish.
    Species reactivity (tested):Rat.
    Purification
    Sequential Chromatography on phospho- and dephosphopeptide affinity columns.
    Immunogène
    Phosphopeptide corresponding to amino acid residues surrounding the phospho-Tyr1472 of NMDA NR2B.
    Isotype
    IgG
    Top Product
    Discover our top product GRIN2B Anticorps primaire
  • Indications d'application
    Western blot: 1/1000.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg/mL BSA and 50 % Glycerol.
    Conseil sur la manipulation
    Avoid repeated freezing and thawing.
    Stock
    -20 °C
    Stockage commentaire
    Store the antibody undiluted (in aliquots) at-20 °C.
  • Hayano, Takasu, Koyama, Yamada, Ogawa, Minami, Asaki, Kitada, Kuwabara, Yamashita: "Dorsal horn interneuron-derived Netrin-4 contributes to spinal sensitization in chronic pain via Unc5B." dans: The Journal of experimental medicine, Vol. 213, Issue 13, pp. 2949-2966, (2017) (PubMed).

    Gladding, Sepers, Xu, Zhang, Milnerwood, Lombroso, Raymond: "Calpain and STriatal-Enriched protein tyrosine phosphatase (STEP) activation contribute to extrasynaptic NMDA receptor localization in a Huntington's disease mouse model." dans: Human molecular genetics, Vol. 21, Issue 17, pp. 3739-52, (2012) (PubMed).

    Xu, Kurup, Bartos, Patriarchi, Hell, Lombroso: "Striatal-enriched protein-tyrosine phosphatase (STEP) regulates Pyk2 kinase activity." dans: The Journal of biological chemistry, Vol. 287, Issue 25, pp. 20942-56, (2012) (PubMed).

  • Antigène
    GRIN2B (Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2B (GRIN2B))
    Autre désignation
    NMDAR2B (GRIN2B Produits)
    Synonymes
    anticorps NMDAR2B, anticorps GluN2B, anticorps MRD6, anticorps NR2B, anticorps hNR3, anticorps nmdar2b, anticorps nr2b, anticorps AW490526, anticorps Nmdar2b, anticorps glutamate ionotropic receptor NMDA type subunit 2B, anticorps glutamate receptor, ionotropic, N-methyl D-aspartate 2B L homeolog, anticorps glutamate receptor, ionotropic, NMDA2B (epsilon 2), anticorps GRIN2B, anticorps Grin2b, anticorps grin2b.L
    Sujet
    The ion channels activated by glutamate that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR). The NMDAR plays an essential role in memory, neuronal development and it has also been implicated in several disorders of the central nervous system including Alzheimer's, epilepsy and ischemic neuronal cell death (Grosshans et al., 2002, Wenthold et al., 2003, Carroll and Zukin, 2002). The NMDA receptor is also one of the principal molecular targets for alcohol in the CNS (Lovinger et al., 1989, Alvestad et al., 2003, Snell et al., 1996). Channels with physiological characteristics are produced when the NR1 subunit is combined with one or more of the NMDAR2 (NR2 A-D) subunits (Ishii et al., 1993). Overexpression of the NR2B-subunit of the NMDA Receptor has been associated with increases in learning and memory while aged, memory impaired animals have deficiencies in NR2B expression (Clayton et al., 2002a, Clayton et al., 2002b). Recent work suggests that phosphorylation of Tyr1472 on NR2B may regulate the functional expression the receptor in LTP and other forms of plasticity (Nakazawa et al., 2001, Roche et al., 2001).Synonyms: GRIN2B, Glutamate [NMDA] receptor subunit epsilon-2, N-methyl D-aspartate receptor subtype 2B, N-methyl-D-aspartate receptor subunit 3, NMDA Receptor 2B
    ID gène
    2904
    NCBI Accession
    NP_000825
    UniProt
    Q13224
    Pathways
    Response to Growth Hormone Stimulus, Synaptic Membrane, Feeding Behaviour, Regulation of long-term Neuronal Synaptic Plasticity
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