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Axin anticorps (C-Term)

AXIN1 Reactivité: Humain, Souris, Rat, Chien IHC (p), EIA Hôte: Chèvre Polyclonal unconjugated
N° du produit ABIN372934
  • Antigène Voir toutes Axin (AXIN1) Anticorps
    Axin (AXIN1) (Axin 1 (AXIN1))
    Épitope
    • 15
    • 15
    • 15
    • 14
    • 11
    • 11
    • 8
    • 8
    • 7
    • 6
    • 6
    • 6
    • 5
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivité
    • 89
    • 53
    • 32
    • 2
    • 1
    Humain, Souris, Rat, Chien
    Hôte
    • 115
    • 7
    • 1
    Chèvre
    Clonalité
    • 116
    • 7
    Polyclonal
    Conjugué
    • 37
    • 11
    • 10
    • 10
    • 6
    • 6
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    Cet anticorp Axin est non-conjugé
    Application
    • 101
    • 49
    • 39
    • 39
    • 31
    • 11
    • 9
    • 8
    • 5
    • 5
    • 3
    • 2
    • 2
    • 1
    Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Séquence
    c-FEEKIIGKVE KVD
    Specificité
    This antibody recognizes Axin 1 (AXIN1).
    Réactivité croisée (Details)
    Species reactivity (expected):Canine (Dog), Mouse and Rat.
    Species reactivity (tested):Human.
    Purification
    Immunoaffinity Chromatography.
    Immunogène
    Synthetic peptide from C-terminus of Human AXIN1.
    Isotype
    IgG
    Top Product
    Discover our top product AXIN1 Anticorps primaire
  • Indications d'application
    ELISA: 1/28000. Immunohistochemistry on Paraffin Sections: 3.75 μg/mL.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    0.5 mg/mL
    Buffer
    Tris-Saline, pH 7.3 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA as stabilizer.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freezing and thawing.
    Stock
    4 °C/-20 °C
    Stockage commentaire
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
  • Antigène
    Axin (AXIN1) (Axin 1 (AXIN1))
    Autre désignation
    Axin-1 (AXIN1 Produits)
    Synonymes
    anticorps AXIN1, anticorps axin, anticorps fused, anticorps xAxin, anticorps LOC100226467, anticorps AXIN, anticorps PPP1R49, anticorps AI316800, anticorps Axin, anticorps Fu, anticorps Kb, anticorps Ki, anticorps kinky, anticorps knobbly, anticorps AXIN1-RGS, anticorps wu:fi22e03, anticorps wu:fj14c08, anticorps wu:fk11b03, anticorps zgc:109872, anticorps axin 1, anticorps axin 1 S homeolog, anticorps axin 1 L homeolog, anticorps AXIN1, anticorps axin1.S, anticorps axin1.L, anticorps Axin1, anticorps axin1
    Sujet
    Axin-1 (Axis inhibition protein 1) and Axin-2 are multidomain scaffold proteins that negatively regulate Wnt signaling. Axin-1 interacts with APC, GSK3-beta, Dvl and beta-Catenin and promotes the GSK3-beta-mediated phosphorylation and subsequent degradation of beta-Catenin (1,2). Upon stimulation of cells with Wnt, Axin1 is recruited to the membrane by phosphorylated LRP5/6, a process that is believed to be crucial for activation of Wnt signaling (3,4). In addition to its role in the Wnt signaling pathway, Axin1 forms a complex with MEKK1 and activates c-Jun amino-terminal kinase (JNK/SAPK) (5). Axin2 (also known as Conductin or Axil) can functionally substitute Axin1 in mice (6). Axin-2 itself is a direct target of the Wnt signaling pathway and therefore serves to control the duration and/or intensity of Wnt signaling through a negative feedback loop (7-9).Synonyms: AXIN, AXIN1, Axis inhibition protein 1
    ID gène
    8312
    NCBI Accession
    NP_003493
    UniProt
    O15169
    Pathways
    Signalisation WNT, Sensory Perception of Sound, Regulation of G-Protein Coupled Receptor Protein Signaling
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