SOCS3 anticorps (C-Term)

N° du produit ABIN374066

Détail du produit anti-SOCS3 anticorps

Antigène: SOCS3 (Suppressor of Cytokine Signaling 3 (SOCS3))

Épitope: C-Term

Reactivité: Humain, Souris, Rat, Porc, Boeuf (Vache), Chien

Hôte: Chèvre

Clonalité: Polyclonal

Conjugué: Cet anticorp SOCS3 est non-conjugé

Application: Western Blotting (WB)

Séquence: C-PIREFLDQYD APL

Specificité: This antibody detects SOCS3 at C-term.

Réactivité croisée (Details): Species reactivity (expected):Mouse, Rat, canine (Dog), Pig, Cow.
Species reactivity (tested):Human.

Purification: Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide

Immunogène: Peptide with sequence from the C Terminus of the protein sequence according to NP_003946.3. Genename: SOCS3

Information d'application

Indications d'application: ELISA: Limit dilution: 1/16000. Western Blot: 4-6 μg/mL. Approx 24 kDa band observed in MOLT-4 lysate.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: Tris saline, pH 7.3 containing 0.02 % Sodium Azide and 0.5 % BSA

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur SOCS3

Antigène: SOCS3 (Suppressor of Cytokine Signaling 3 (SOCS3))

Autre désignation: SOCS3 / CIS3 (SOCS3 Produits)

Synonymes: anticorps socs3, anticorps fj09e12, anticorps zgc:56537, anticorps wu:fj09e12, anticorps MGC64393, anticorps MGC75749, anticorps xsocs3, anticorps MGC81248, anticorps atod4, anticorps cis3, anticorps cish3, anticorps socs-3, anticorps ssi-3, anticorps ssi3, anticorps SOCS3, anticorps ATOD4, anticorps CIS3, anticorps Cish3, anticorps SOCS-3, anticorps SSI-3, anticorps SSI3, anticorps Cis3, anticorps EF-10, anticorps Ef10, anticorps Ssi3, anticorps Socs-3, anticorps Ssi-3, anticorps suppressor of cytokine signaling 3a, anticorps suppressor of cytokine signaling 3 S homeolog, anticorps suppressor of cytokine signaling 3, anticorps suppressor of cytokine signaling 3 L homeolog, anticorps socs3a, anticorps socs3.S, anticorps socs3, anticorps socs3.L, anticorps SOCS3, anticorps Socs3

Sujet: Accumulating evidence demonstrates that cytokine receptor signaling is negatively regulated by a family of Src homology 2 domain-containing adaptor molecules Termed SOCS (Suppressor of Cytokine Signaling). To date, there are eight members of SOCS family have been recognized, they are SOCS-1, 2, 3, 4, 5, 6, 7 and CIS. Structurally the SOCS proteins are composed of an N-terminal region of variable length and amino acid composition, a central SH2 domain, and a previously unrecognized C-terminal motif that we have called the SOCS box. The SOCS proteins appear to form part of a classical negative feed back loop that regulates cytokine signal transduction via a STAT-induced transcriptional mechanism. Transcription of each of the SOCS genes occurs rapidly in vitro and in vivo in response to cytokines, and once produced, the various members of the SOCS family appear to inhibit signaling in different ways.Synonyms: CIS-3, Cytokine-inducible SH2 protein 3, SOCS-3, SSI-3, SSI3, STAT-induced STAT inhibitor 3, Suppressor of cytokine signaling 3

ID gène: 9021

NCBI Accession: NP_003946

UniProt: O14543

Pathways: Signalistation JAK/STAT, Response to Growth Hormone Stimulus, Hepatitis C