PTGS1 anticorps (C-Term)

N° du produit ABIN374151

Détail du produit anti-PTGS1 anticorps

Antigène: PTGS1 (Prostaglandin-Endoperoxide Synthase 1 (Prostaglandin G/H Synthase and Cyclooxygenase) (PTGS1))

Épitope: C-Term

Reactivité: Humain

Hôte: Chèvre

Clonalité: Polyclonal

Conjugué: Cet anticorp PTGS1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Séquence: C-QDDGPAVERP STEL

Specificité: This antibody is expected to recognize both Human isoforms of COX1 according to NP_000953.2 and NP_542158.1.

Réactivité croisée (Details): Species reactivity (tested):Human.

Purification: Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide

Immunogène: Peptide with sequence from the C Terminus of the protein sequence Genename: PTGS1

Information d'application

Indications d'application: Peptide ELISA: Limit dilution 1: 32000. Western blot: 1 - 3 μg/mL. Approx 65-70 kDa bands seen in HeLa lysate. Immunohistochemistry on paraffin sections: 3 - 5 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: Tris saline, pH ~7.3 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA as stabilizer

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur PTGS1

Antigène: PTGS1 (Prostaglandin-Endoperoxide Synthase 1 (Prostaglandin G/H Synthase and Cyclooxygenase) (PTGS1))

Autre désignation: Cyclooxygenase 1 (PTGS1 Produits)

Synonymes: anticorps COX-1, anticorps cox-1, anticorps PTGS1, anticorps Ptgs1, anticorps COX1, anticorps Cox-1, anticorps Cox-3, anticorps PGHS-1, anticorps PHS 1, anticorps Pghs1, anticorps Cox1, anticorps Cox3, anticorps cox1, anticorps zCOX-1, anticorps COX3, anticorps PCOX1, anticorps PES-1, anticorps PGG/HS, anticorps PGHS1, anticorps PHS1, anticorps PTGHS, anticorps COX-3, anticorps prostaglandin-endoperoxide synthase 1, anticorps cyclooxygenase-1, anticorps prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase), anticorps prostaglandin-endoperoxide synthase 1 S homeolog, anticorps PTGS1, anticorps cox-1, anticorps Ptgs1, anticorps ptgs1, anticorps ptgs1.S

Sujet: Cyclooxygenase (COX), also known as Prostaglandin H2 synthase and Prostaglandin endoperoxide synthase, is a key enzyme in the of conversion arachidonic acid to Prostaglandin H2. Prostaglandin H2 is converted by other enzymes into inflammatory mediators prostaglandin (PG) D2, PGE2, PGF2a, PGI2 and Thromboxane A2. Thus, COX is a key enzyme in the production of inflammatory agents and is the target of intense research and drug discovery activities. There are two enzymes of COX, COX 1 and COX 2. COX 1 is constitutively produced in many (most) cell types. It is important in the gut for the production of prostaglandins, which inhibit gastric secretion. It can be induced in monocytes, macrophages and other cells. It is induced as part of the inflammatory response by IL 1beta and other cytokines. It is induced by growth factors such as EGF and PDGF. Expression is inhibited by glucocorticosteroids such as cortisol and dexamethasone. Lipopolysaccharide in bacterial infections induces COX 2. COX 2 is also found in elevated levels in synoviocytes from rheumatoid arthritis patients. The discomforts of inflammation such as pain and swelling are largely due to the action of prostaglandins produced by COX2.Synonyms: COX-1, COX1, Cyclooxygenase-1, PGH synthase 1, PGHS-1, PTGS1, Prostaglandin G/H synthase 1, Prostaglandin H2 synthase 1, Prostaglandin-endoperoxide synthase 1

Poids moléculaire: 64.5kDa (NP_542158.1) and 68.7kDa (NP_000953.2)

ID gène: 5742

NCBI Accession: NP_000953

UniProt: P23219