ALS2 anticorps (C-Term)

N° du produit ABIN374168

Détail du produit anti-ALS2 anticorps

Antigène: ALS2 (Amyotrophic Lateral Sclerosis 2 (Juvenile) (ALS2))

Épitope: C-Term

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Chien

Hôte: Chèvre

Clonalité: Polyclonal

Conjugué: Cet anticorp ALS2 est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Séquence: LKACYYQIQR EKLN

Specificité: This antibody detects Alsin / ALS2 at C-term.

Purification: Ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide

Immunogène: Peptide from C Terminus of the protein sequence according to NP_065970.2 Genename: ALS2

Information d'application

Indications d'application: Peptide ELISA: Limit dilution 1: 8000. Immunohistochemistry: 3-5 μg/mL. In paraffin embedded Human Cortex shows pixulatecytoplasm staining in some neuronal cells.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C.

Détails sur ALS2

Antigène: ALS2 (Amyotrophic Lateral Sclerosis 2 (Juvenile) (ALS2))

Autre désignation: Alsin / ALS2 (ALS2 Produits)

Synonymes: anticorps als2, anticorps si:dkey-33m14.1, anticorps ALS2CR6, anticorps ALSJ, anticorps IAHSP, anticorps PLSJ, anticorps 3222402C23Rik, anticorps 9430073A21Rik, anticorps Als2cr6, anticorps Alsin, anticorps mKIAA1563, anticorps amyotrophic lateral sclerosis 2a (juvenile), anticorps alsin, anticorps ALS2, alsin Rho guanine nucleotide exchange factor, anticorps amyotrophic lateral sclerosis 2 (juvenile), anticorps als2a, anticorps CpipJ_CPIJ008258, anticorps CpipJ_CPIJ008260, anticorps ALS2, anticorps Als2

Sujet: ALS2 specifically binds to, and functions as a guanine nucleotide exchange factor (GEF) for the small GTPase RAB5. ALS2 contains an ATS1/RCC1-like domain, a RhoGEF domain, and a vacuolar protein sorting 9 (VPS9) domain, all of which are guanine-nucleotide exchange factors that activate members of the Ras superfamily of GTPases. The protein localizes with RAB5 on early endosomal compartments, and functions as a modulator for endosomal dynamics. Loss of ALS2 function might underlie neuronal dysfunction and degeneration in a number of motor neuron diseases.Synonyms: ALS2CR6, Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 6 protein, Amyotrophic lateral sclerosis protein 2, KIAA1563

ID gène: 57679

NCBI Accession: NP_065970

UniProt: Q96Q42

Pathways: Skeletal Muscle Fiber Development