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IRF8 anticorps (C-Term)

IRF8 Reactivité: Humain, Souris, Rat, Boeuf (Vache) WB Hôte: Chèvre Polyclonal unconjugated
N° du produit ABIN374256
  • Antigène Voir toutes IRF8 Anticorps
    IRF8 (Interferon Regulatory Factor 8 (IRF8))
    Épitope
    • 9
    • 7
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivité
    • 32
    • 25
    • 11
    • 5
    • 4
    • 4
    • 4
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain, Souris, Rat, Boeuf (Vache)
    Hôte
    • 44
    • 2
    • 1
    Chèvre
    Clonalité
    • 46
    • 1
    Polyclonal
    Conjugué
    • 33
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp IRF8 est non-conjugé
    Application
    • 27
    • 17
    • 10
    • 7
    • 6
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB)
    Séquence
    C-QRSFFRENQQ ITV
    Specificité
    This antibody detects IRF8 / ICSBP1 at C-term.
    Réactivité croisée (Details)
    Species reactivity (expected):Mouse, Rat, CowSpecies reactivity (tested):Human
    Purification
    Ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
    Immunogène
    Peptide from C Terminus of the protein sequence according to NP_002154.1 Genename: IRF8
    Top Product
    Discover our top product IRF8 Anticorps primaire
  • Indications d'application
    Peptide ELISA: Limit dilution 1: 8000. Western blot: 0.5-2 μg/mL. Approx 45-50 kDa band seen in K562 lysate.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    0.5 mg/mL
    Buffer
    Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freezing and thawing.
    Stock
    4 °C/-20 °C
    Stockage commentaire
    Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C.
  • Antigène
    IRF8 (Interferon Regulatory Factor 8 (IRF8))
    Autre désignation
    IRF8 / ICSBP1 (IRF8 Produits)
    Synonymes
    anticorps zgc:92252, anticorps IRF8, anticorps MGC140338, anticorps DKFZp469B0320, anticorps H-ICSBP, anticorps ICSBP, anticorps ICSBP1, anticorps IRF-8, anticorps icsbp1, anticorps AI893568, anticorps Icsbp1, anticorps Myls, anticorps interferon regulatory factor 8, anticorps interferon regulatory factor 8 L homeolog, anticorps irf8, anticorps IRF8, anticorps irf8.L, anticorps Irf8
    Sujet
    Interferon regulatory factor 8 (IRF8) / Interferon consensus sequence binding protein (ICSBP) is a transcription factor of the interferon (IFN) regulatory factor (IRF) family. Proteins of this family are composed of a conserved DNA binding domain in the N terminal region and a divergent C terminal region that serves as the regulatory domain. The IRF family proteins bind to the IFN stimulated response element (ISRE) and regulate expression of genes stimulated by type I IFNs, namely IFN alpha and IFN beta. IRF family proteins also control expression of IFN alpha and IFN beta regulated genes that are induced by viral infection. IRF8 specifically binds to the upstream regulatory region of type I IFN and IFN inducible MHC class I genes (the interferon consensus sequence (ICS)). Unlike IRF3, IRF8 appears to act as a negative regulator of IFN induced genes in most cases, but IRF8 mediates activation of NF kappaB by the toll like receptor 9 (TLR9) after stimulation by unmethylated CpG DNA in dendritic cells. Finally, it has been shown that IRF8 decreases bcl 2 expression and thus may play a role in chronic myelogenous leukemia.Synonyms: IRF-8, Interferon consensus sequence-binding protein, Interferon regulatory factor 8
    ID gène
    3394
    NCBI Accession
    NP_002154
    UniProt
    Q02556
    Pathways
    Cellular Response to Molecule of Bacterial Origin
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