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LCP2 anticorps (N-Term)

LCP2 Reactivité: Humain, Souris, Rat, Porc, Boeuf (Vache), Chien WB, EIA Hôte: Chèvre Polyclonal unconjugated
N° du produit ABIN374443
  • Antigène Voir toutes LCP2 Anticorps
    LCP2 (Lymphocyte Cytosolic Protein 2 (SH2 Domain Containing Leukocyte Protein of 76kDa) (LCP2))
    Épitope
    • 20
    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivité
    Humain, Souris, Rat, Porc, Boeuf (Vache), Chien
    Hôte
    • 47
    • 16
    • 1
    Chèvre
    Clonalité
    • 43
    • 21
    Polyclonal
    Conjugué
    • 40
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Cet anticorp LCP2 est non-conjugé
    Application
    • 35
    • 12
    • 11
    • 8
    • 7
    • 6
    • 6
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    Western Blotting (WB), Enzyme Immunoassay (EIA)
    Séquence
    C-ALRNVPFRSE V
    Specificité
    This antibody recognizes LCP2.
    Réactivité croisée (Details)
    Species reactivity (expected):Mouse, Rat, Canine, Pig, Cow.
    Species reactivity (tested):Human.
    Purification
    Ammonium Sulphate Precipitation followed by antigen Affinity Chromatography using the immunizing peptide.
    Immunogène
    Peptide from the N Terminus of the protein sequence according to NP_005556.
    Top Product
    Discover our top product LCP2 Anticorps primaire
  • Indications d'application
    Peptide ELISA: 1/32,000. Western Blot: 0.5-2 μg/mL. Detects a band of Approx 75 kDa (Predicted Molecular Weight65 kDa). Positive Control: Jurkat lysates.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    0.5 mg/mL
    Buffer
    Tris saline, pH 7.3 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA as stabilizer.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freezing and thawing.
    Stock
    -20 °C
    Stockage commentaire
    Store the antibody undiluted (in aliquots) at -20 °C.
  • Antigène
    LCP2 (Lymphocyte Cytosolic Protein 2 (SH2 Domain Containing Leukocyte Protein of 76kDa) (LCP2))
    Autre désignation
    LCP2 (LCP2 Produits)
    Synonymes
    anticorps AI323664, anticorps BB161688, anticorps SLP-76, anticorps SLP76, anticorps twm, anticorps Slp76, anticorps lymphocyte cytosolic protein 2, anticorps Lcp2, anticorps LCP2
    Sujet
    LCP2 is a hematopoietic cell-specific adaptor protein that is crucial for T-cell receptor (TCR) signaling, hemostasis and platelet function. TCR ligation and fibrinogen binding to integrin alpha 2 beta 3 stimulates the phosphorylation of the tyrosine residues in the amino terminus, and facilitates SLP76 binding to the SH2 domain of Vav, which can activate JNK. SLP76 also comprises a proline-rich domain region that associates with the SH3 domain of Grb2 linking SLP76 to the Ras to Raf to ERK1 & 2 signaling pathway, LAT, PLC gamma, Fyn-binding protein (SLAP130), the SH2 containing phosphatase 1 and Nck, which mediates the regulation of cytoskeletal actin polymerization. Phosphorylation of tyrosine 145 has been shown to be important for optimal SLP76 function.Synonyms: LCP2, Lymphocyte cytosolic protein 2, SH2 domain-containing leukocyte protein of 76 kDa, SLP-76 tyrosine phosphoprotein, SLP76
    ID gène
    3937
    NCBI Accession
    NP_005556
    UniProt
    Q13094
    Pathways
    TCR Signaling, Fc-epsilon Receptor Signaling Pathway
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