Survivin anticorps (C-Term)

N° du produit ABIN374456

Détail du produit anti-Survivin anticorps

Antigène: Survivin (BIRC5) (Baculoviral IAP Repeat-Containing 5 (BIRC5))

Épitope: C-Term

Reactivité: Humain

Hôte: Chèvre

Clonalité: Polyclonal

Conjugué: Cet anticorp Survivin est non-conjugé

Application: Western Blotting (WB)

Specificité: This antibody reacts to Apoptosis inhibitor survivin.

Purification: Affinity chromatography

Immunogène: Peptide with sequence CVRRAIEQLAAMD, from the C Terminus of the protein sequence

Information d'application

Indications d'application: Peptide ELISA: 1/16000. Western blot: 0.01 - 0.5 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 0,5 mg/mL

Buffer: Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur Survivin

Antigène: Survivin (BIRC5) (Baculoviral IAP Repeat-Containing 5 (BIRC5))

Autre désignation: IAP4 / BIRC5 (BIRC5 Produits)

Synonymes: anticorps AP14, anticorps API4, anticorps EPR-1, anticorps AAC-11, anticorps Api4, anticorps TIAP, anticorps survivin40, anticorps bir5a, anticorps survivin, anticorps BIR1, anticorps Su2, anticorps XBIR1, anticorps XSurvivin1, anticorps Xsvv1, anticorps api4, anticorps bir1-A, anticorps epr-1, anticorps svv1, anticorps xSurvivin, anticorps xsurv, anticorps Su1, anticorps birc5.2, anticorps svv2, anticorps xSurvivin2, anticorps bir5b, anticorps SIX, anticorps birc5.2-a, anticorps birc5.2-b, anticorps baculoviral IAP repeat containing 5, anticorps baculoviral IAP repeat-containing 5, anticorps baculoviral IAP repeat containing 5a, anticorps baculoviral IAP repeat-containing 5, gene 1 L homeolog, anticorps baculoviral IAP repeat containing 5 L homeolog, anticorps baculoviral IAP repeat containing 5b, anticorps baculoviral IAP repeat containing 5 S homeolog, anticorps BIRC5, anticorps Birc5, anticorps birc5a, anticorps birc5.1.L, anticorps birc5.2.L, anticorps birc5b, anticorps birc5.2.S

Sujet: Survivin is an anti-apoptotic protein, expressed in the G2/M cell cycle phase. At the onset of mitosis, survivin associates with microtubules of the mitotic spindle in a specific and saturable reaction that is regulated by microtubule dynamics. Disruption of survivin-microtubule interactions results in loss of survivin's anti-apoptotic function and increased caspase 3 activity. Survivin is also abundantly expressed in brain tissues (astrocytes and some neurons) of adult rats following traumatic brain injury. Survivin has been found co-expressed with NeuN (mature neuronal marker) and PCNA (a cell cycle protein. Survivin might affect regulation of neural cell proliferative responses after brain injury. Survivin is also an inhibitor of apoptosis (IAP), or programmed cell death, that is selectively overexpressed in common human cancers.Synonyms: API4, Apoptosis inhibitor 4, Apoptosis inhibitor survivin, Baculoviral IAP repeat-containing protein 5, Survivin

ID gène: 332

NCBI Accession: NP_001012270

UniProt: O15392

Pathways: Apoptose, Cycle Cellulaire, Nuclear Hormone Receptor Binding