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PVALB anticorps (C-Term)

PVALB Reactivité: Humain, Rat WB, IHC (p) Hôte: Chèvre Polyclonal unconjugated
N° du produit ABIN374572
  • Antigène Voir toutes PVALB Anticorps
    PVALB (Parvalbumin (PVALB))
    Épitope
    • 15
    • 7
    • 7
    • 4
    • 1
    • 1
    C-Term
    Reactivité
    • 40
    • 36
    • 29
    • 15
    • 1
    Humain, Rat
    Hôte
    • 49
    • 20
    • 2
    • 1
    Chèvre
    Clonalité
    • 43
    • 29
    Polyclonal
    Conjugué
    • 23
    • 6
    • 5
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp PVALB est non-conjugé
    Application
    • 40
    • 30
    • 26
    • 16
    • 16
    • 13
    • 13
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Séquence
    C-GVDEFSTLVA ES
    Specificité
    This antibody recognizes Parvalbumin.
    Réactivité croisée (Details)
    Species reactivity (tested):Human, Rat.
    Purification
    Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide.
    Immunogène
    Peptide with sequence from the C Terminus of the protein sequence according to NP_002845.1.
    Top Product
    Discover our top product PVALB Anticorps primaire
  • Indications d'application
    Peptide ELISA: 1/32000. Western Blot: 0.1-0.3 μg/mL. Approx 12 kDa band observed in Human Brain lysates (calculated MW of 12.2 kDa accordingto NP_002845.1). Approx 10-12 kDa band observed in rat skeletal muscle and in rat heart cells transfectedwith human PVALB, but not in untransfected rat heart cells. (1)
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    0.5 mg/mL
    Buffer
    Tris saline, pH ~7.3, 0.02 % Sodium Azide, 0.5 % BSA
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freezing and thawing.
    Stock
    4 °C/-20 °C
    Stockage commentaire
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Antigène
    PVALB (Parvalbumin (PVALB))
    Autre désignation
    Parvalbumin alpha / PVALB (PVALB Produits)
    Synonymes
    anticorps D22S749, anticorps PV, anticorps Parv, anticorps Pva, anticorps PALB1, anticorps pvalb1, anticorps MGC107903, anticorps parvalbumin, anticorps parvalbumin, gene 1, anticorps parvalbumin, gene 1 S homeolog, anticorps PVALB, anticorps Pvalb, anticorps pvalb.1, anticorps pvalb.1.S
    Sujet
    Parvalbumin (PV) is a calcium binding protein expressed in specific muscle fibers and fast-firing neurons. PV consists of a single, unbranched chain of linked amino acids and belongs to a larger group of EF hand proteins. Studies have demonstrated that parvalbumin acts in the decay of calcium in the contraction/ relaxation cycle of fast twitch muscles. This data has shown a positive correlation between the rate of relaxation and the concentration of parvalbumin. Parvalbumin is also expressed in a specific population of GABAergic interneurones which are thought to play a role in maintaining the balance between excitation and inhibition in the cortex as well as the hippocampus. In amyotrophic lateral sclerosis (ALS) patents, parvalbumin immunoreactivity is specifically absent from neuron populations lost early in ALS.
    ID gène
    5816
    NCBI Accession
    NP_002845
    UniProt
    P20472
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