CACNA2D1 anticorps (Internal Region)

N° du produit ABIN374788

Détail du produit anti-CACNA2D1 anticorps

Antigène: CACNA2D1 (Calcium Channel, Voltage-Dependent, alpha 2/delta Subunit 1 (CACNA2D1))

Épitope: Internal Region

Reactivité: Humain

Hôte: Chèvre

Clonalité: Polyclonal

Conjugué: Cet anticorp CACNA2D1 est non-conjugé

Application: Western Blotting (WB)

Séquence: C-QEIFNKYNKD KKVR

Specificité: This antibody recognizes CACNA2D1.

Réactivité croisée (Details): Species reactivity (tested):Human.

Purification: Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide

Immunogène: Synthetic peptide from the internal region of Human CACNA2D1 (NP_000713.2) Genename: CACNA2D1

Information d'application

Indications d'application: Peptide ELISA: 1/16000. Western Blot: 0.03 - 0.1 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: Tris saline, pH ~7.3, 0.02 % Sodium Azide, 0.5 % BSA

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur CACNA2D1

Antigène: CACNA2D1 (Calcium Channel, Voltage-Dependent, alpha 2/delta Subunit 1 (CACNA2D1))

Autre désignation: CACNA2D1 (CACNA2D1 Produits)

Synonymes: anticorps CACNA2D1, anticorps DKFZp469K2211, anticorps CACNA2, anticorps CACNL2A, anticorps CCHL2A, anticorps Ca(v)alpha2delta1, anticorps Cacna2, anticorps Cchl2a, anticorps CCHLA2, anticorps DHSCCA, anticorps calcium voltage-gated channel auxiliary subunit alpha2delta 1, anticorps calcium channel, voltage-dependent, alpha 2/delta subunit 1, anticorps calcium channel, voltage-dependent, alpha2/delta subunit 1, anticorps CACNA2D1, anticorps cacna2d1, anticorps Cacna2d1

Sujet: Voltage-sensitive calcium channels mediate the entry of calcium into many types of excitable cells and thus play a key role in neurotransmitter release and excitation-contraction (E-C) coupling. The 1,4-dihydropyridines (DHPs) are synthetic organic compounds which can be used to identify the L-type calcium channels that are found in all types of vertebrate muscle, neuronal and neuroendocrine cells. The DHP receptor is part of the L-type calcium channel complex and is thought to be the voltage sensor in E-C coupling. The purified DHP receptor isolated from triads is composed of at least four subunits. The alpha-1 subunit contains the binding site for the DHPs and shows high sequence homology to the voltage gated sodium channel. The alpha-2 subunit is a large glycoprotein associated with the DHP receptor which was first described in skeletal muscle and is also found in high concentrations in other excitable tissues such as cardiac muscle and brain and in low concentrations in most other tissues studied. The other two subunits that co-purify with the DHP receptor are termed beta and gamma.Synonyms: CACNL2A, CCHL2A, MHS3, Voltage-dependent calcium channel subunit alpha-2/delta-1

Poids moléculaire: 123 kDa (NP_000713.2)

ID gène: 781, 9606

UniProt: P54289