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ACVR1 anticorps (Internal Region)

ACRV1 Reactivité: Humain, Souris, Rat, Chien WB Hôte: Chèvre Polyclonal unconjugated
N° du produit ABIN374913
  • Antigène Voir toutes ACVR1 (ACRV1) Anticorps
    ACVR1 (ACRV1) (Activin Receptor Type I (ACRV1))
    Épitope
    • 22
    • 20
    • 10
    • 7
    • 7
    • 7
    • 6
    • 6
    • 6
    • 6
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reactivité
    • 87
    • 42
    • 16
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    Humain, Souris, Rat, Chien
    Hôte
    • 83
    • 5
    • 3
    • 3
    Chèvre
    Clonalité
    • 91
    • 3
    Polyclonal
    Conjugué
    • 49
    • 15
    • 6
    • 6
    • 6
    • 6
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp ACVR1 est non-conjugé
    Application
    • 85
    • 57
    • 45
    • 14
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    Western Blotting (WB)
    Specificité
    This antibody reacts to ACVR1.
    Réactivité croisée (Details)
    Species reactivity (expected):Mouse, Rat, Canine.
    Species reactivity (tested):Human.
    Purification
    Affinity chromatography
    Immunogène
    Peptide with sequence C-RKFKRRNQERLNPRD, from the internal region of the protein sequence
    Top Product
    Discover our top product ACRV1 Anticorps primaire
  • Indications d'application
    Peptide ELISA: 1/128000. Western Blot: 0.3 - 1 μg/mL. Immunohistochemistry on paraffin sections: 4 - 6 μg/mL.
    Restrictions
    For Research Use only
  • Concentration
    0,5 mg/mL
    Buffer
    Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freezing and thawing.
    Stock
    4 °C/-20 °C
    Stockage commentaire
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Antigène
    ACVR1 (ACRV1) (Activin Receptor Type I (ACRV1))
    Abstract
    ACRV1 Produits
    Synonymes
    anticorps ACTRI, anticorps ACVR1A, anticorps ACVRLK2, anticorps ALK2, anticorps FOP, anticorps SKR1, anticorps TSRI, anticorps ActR-IA, anticorps ActR-I, anticorps ActRIA, anticorps Acvr, anticorps Acvrlk2, anticorps Alk-2, anticorps Alk8, anticorps D330013D15Rik, anticorps Tsk7L, anticorps actri, anticorps acvr1, anticorps acvr1-a, anticorps acvr1-b, anticorps acvr1a, anticorps acvrlk2, anticorps alk-2, anticorps alk2, anticorps alk8, anticorps fop, anticorps sax, anticorps skr1, anticorps tsri, anticorps xALK-2, anticorps activin A receptor type 1, anticorps activin A receptor, type 1, anticorps activin A receptor type 1 S homeolog, anticorps ACVR1, anticorps Acvr1, anticorps acvr1.S
    Sujet
    Activin Receptor Type IA on ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Activin receptor IA is highly conserved and is a receptor for BMP2 and BMP4. Activin type I receptors transduce signals for a variety of members of the Transforming growth factor beta superfamily of ligands. This family of cytokines and hormones inlude activin, Anti-müllerian hormone (AMH), bone morphogenetic proteins (BMPs), and Nodal. They are involved in a host of physiological processes including, growth, cell differentiation, homeostasis, osteogenesis, apoptosis and many other functions. There are three type I Activin receptors:ACVR1, ACVR1B, and ACVR1C Each bind to a specific type II receptor-ligand complex. Despite the large amount of processes that these ligands regulate, they all operate through essentially the same pathway: A ligand binds to a Type two receptor, which recruits and trans-phosphorylate a type I receptor. The type I receptor recruits a receptor regulated SMAD (R-SMAD) which it phosphorylates. The RSMAD then translocates to the nucleus where it functions as a transcription factor.Synonyms: ACRV1A, ACVRLK2, ALK2, Activin receptor type IA, Activin receptor-like kinase 2, SKR1, Serine/threonine-protein kinase receptor R1, TGF-B superfamily receptor type I
    ID gène
    90, 9606
    UniProt
    Q04771
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