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HAP1 anticorps (Internal Region)

HAP1 Reactivité: Humain WB, EIA Hôte: Chèvre Polyclonal unconjugated
N° du produit ABIN375206
  • Antigène Voir toutes HAP1 Anticorps
    HAP1 (Huntingtin Associated Protein 1 (HAP1))
    Épitope
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reactivité
    • 13
    • 6
    • 5
    Humain
    Hôte
    • 12
    • 4
    • 2
    Chèvre
    Clonalité
    • 15
    • 3
    Polyclonal
    Conjugué
    • 15
    • 1
    • 1
    • 1
    Cet anticorp HAP1 est non-conjugé
    Application
    • 14
    • 6
    • 6
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Enzyme Immunoassay (EIA)
    Specificité
    This antibody reacts to HAP1. This antibody is expected to recognize all reported isoforms.
    Purification
    Affinity chromatography
    Immunogène
    Peptide with sequence C-RYDFRYSEDREQ, from the internal region of the protein sequence
    Top Product
    Discover our top product HAP1 Anticorps primaire
  • Indications d'application
    ELISA: 1/32000. Western blot: 0.1 - 0.3 μg/mL.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    0.5 mg/mL
    Buffer
    Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freezing and thawing.
    Stock
    4 °C/-20 °C
    Stockage commentaire
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Antigène
    HAP1 (Huntingtin Associated Protein 1 (HAP1))
    Autre désignation
    HAP1 (HAP1 Produits)
    Synonymes
    anticorps HAP2, anticorps HIP5, anticorps HLP, anticorps hHLP1, anticorps HAP1-A, anticorps HAP1-B, anticorps HAP-1, anticorps huntingtin associated protein 1, anticorps huntingtin-associated protein 1, anticorps HAP1, anticorps Hap1
    Sujet
    Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. It is a progressive disorder that generally begins in middle age with abnormalities of movement, cognition, personality and mood. Huntingtin-associated protein-1 is highly expressed in brain and shown to mediate the neuropathology of HD. The human protein interacts with huntingtin, with two cytoskeletal proteins (dynactin and pericentriolar autoantigen protein 1), and with a hepatocyte growth factor-regulated tyrosine kinase substrate. The interactions with cytoskeletal proteins and a kinase substrate suggest a role for this protein in vesicular trafficking or organelle transport. Two transcripts encoding different isoforms have been identified but one is a nonsense-mediated decay (NMD) candidate.Synonyms: HAP-1, HAP2, HLP1, Huntingtin-associated protein 1, Neuroan 1
    ID gène
    9001
    NCBI Accession
    NP_001073339
    UniProt
    P54257
    Pathways
    Cell RedoxHomeostasis, Smooth Muscle Cell Migration, Positive Regulation of Response to DNA Damage Stimulus
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