NEDD9 anticorps (Internal Region)

N° du produit ABIN375218

Détail du produit anti-NEDD9 anticorps

Antigène: NEDD9 (Neural Precursor Cell Expressed, Developmentally Down-Regulated 9 (NEDD9))

Épitope: Internal Region

Reactivité: Humain, Rat, Souris, Chien

Hôte: Chèvre

Clonalité: Polyclonal

Conjugué: Cet anticorp NEDD9 est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificité: This antibody reacts to NEDD9. This antibody is expected to recognise isoform 1 only.

Réactivité croisée (Details): Species reactivity (expected):Mouse, Rat, Canine.
Species reactivity (tested):Human.

Purification: Affinity chromatography

Immunogène: Peptide with sequence NKPQNKCDDLDR, from the internal region of the protein sequence

Information d'application

Indications d'application: Peptide ELISA: 1/8000. Western Blot: 0.1 - 0.3 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 0,5 mg/mL

Buffer: Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur NEDD9

Antigène: NEDD9 (Neural Precursor Cell Expressed, Developmentally Down-Regulated 9 (NEDD9))

Autre désignation: NEDD9 (NEDD9 Produits)

Synonymes: anticorps NEDD9, anticorps CAS-L, anticorps CAS2, anticorps CASL, anticorps CASS2, anticorps HEF1, anticorps Cas-L, anticorps CasL, anticorps E230025G09Rik, anticorps neural precursor cell expressed, developmentally down-regulated 9, anticorps neural precursor cell expressed, developmentally down-regulated gene 9, anticorps NEDD9, anticorps Nedd9

Sujet: HEF1 is a multifunctional protein involved in integrin-based signaling that affects cell motility, growth, apoptosis and oncogenic transformation. The Cas family of docking proteins have been the subject of intense research because of their role in cell motility, growth, apoptosis and oncogenic transformation. These proteins are substrates of focal adhesion kinase (FAK) and the Src family of tyrosine kinases, two active targets for drug development. HEF1 protein production increases levels of mRNA transcripts that encode proteins associated with motility, cell transformation and invasiveness, including several metalloproteinases, MLCK, p160ROCK and ErbBi. HEF1 overproduction also mediates apoptosis in epithelial-derived cell lines, including MCF7 and HeLa cells. Recent clinical studies at another institution have found that overexpression of BCAR1 (p130Cas), a related protein, is associated with tamoxifen resistance. This highlights the importance of studying the role of this family of proteins in cancer prognosis.Synonyms: CASL, CASS2, Enhancer of filamentation 1, Neural precursor cell expressed developmentally down-regulated protein 9, hEF1

ID gène: 4739

NCBI Accession: NP_001135865

UniProt: Q14511