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ABCC8 anticorps (C-Term)

ABCC8 Reactivité: Humain, Rat, Souris, Chien WB, EIA Hôte: Chèvre Polyclonal unconjugated
N° du produit ABIN375248
  • Antigène Voir toutes ABCC8 Anticorps
    ABCC8 (ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 8 (ABCC8))
    Épitope
    • 12
    • 5
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivité
    • 30
    • 21
    • 7
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain, Rat, Souris, Chien
    Hôte
    • 24
    • 20
    • 1
    Chèvre
    Clonalité
    • 26
    • 19
    Polyclonal
    Conjugué
    • 22
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp ABCC8 est non-conjugé
    Application
    • 31
    • 21
    • 15
    • 14
    • 12
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Enzyme Immunoassay (EIA)
    Specificité
    This antibody reacts to SUR1.
    Réactivité croisée (Details)
    Species reactivity (expected):Mouse, Rat, Canine.
    Species reactivity (tested):Human.
    Purification
    Affinity chromatography
    Immunogène
    Peptide with sequence C-EFDKPEKLLSRKD, from the C Terminus of the protein sequence
    Top Product
    Discover our top product ABCC8 Anticorps primaire
  • Indications d'application
    Peptide ELISA: 1/8000. Western Blot: 0.5 - 1.5 μg/mL.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    0,5 mg/mL
    Buffer
    Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freezing and thawing.
    Stock
    4 °C/-20 °C
    Stockage commentaire
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Antigène
    ABCC8 (ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 8 (ABCC8))
    Autre désignation
    ABCC8 (ABCC8 Produits)
    Synonymes
    anticorps ABC36, anticorps HHF1, anticorps HI, anticorps HRINS, anticorps MRP8, anticorps PHHI, anticorps SUR, anticorps SUR1, anticorps SUR1delta2, anticorps TNDM2, anticorps D930031B21Rik, anticorps Sur, anticorps Sur1, anticorps ATP binding cassette subfamily C member 8, anticorps ATP-binding cassette, sub-family C (CFTR/MRP), member 8, anticorps ABCC8, anticorps Abcc8
    Sujet
    SUR1 is a 1581 amino acid protein with an ATP binding domain with two nucleotide binding folds (NBFs) and binding sites for sulfonylureas, like glibenclamide, and for channel openers. SUR contains three hydrophobic domains, TM(0), TM(1), and TM(2), with nucleotide binding folds following TM(1) and TM(2). The protein is glycosylated at position 10 on Asn. The SUR1 gene is expressed in at least 4 multiple splice variants ere are multiple splice variants, these splice variants originate from the splicing of the coding region of NFB and lack of axon 17 (SUR1 Delta 17), axon 19 (SUR1 Delta 19) and both (SUR1 Delta 17/19) and the fourth is a COOH terminal fragment formed by Exxon 31-39 containing the last 2 TMD and the COOH terminal (SUR1C). The various splice variants of SUR1 are expressed in various tissues with strong expression of SUR1C in cardiomyocytes. Only SUR1 and SUR1Delta 17 exhibit high affinity binding sites for sulfonylurea and other pharmacological agents. Several point mutations in the NFB region of SUR1 are also described in NIDDM. A total of five amino acid substitutions and 17 silent mutations were noted by examining all 39 axons of this gene in NIDDM patients form Japan. Two rare novel mutations, D811N in axon 20 and R835C in axon 21, were identified in the first nucleotide binding fold (NBF), a functionally important region of SUR1, in one patient each, both heterozygotes.Synonyms: ATP-binding cassette transporter sub-family C member 8, HRINS, SUR, SUR1, Sulfonylurea receptor 1
    ID gène
    6833, 9606
    UniProt
    Q09428
    Pathways
    Negative Regulation of Hormone Secretion
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