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DNMT3A anticorps (AA 457-486)

DNMT3A Reactivité: Humain, Souris, Rat WB, IHC (p) Hôte: Lapin Polyclonal RB01852 unconjugated
N° du produit ABIN387881
  • Antigène Voir toutes DNMT3A Anticorps
    DNMT3A (DNA (Cytosine-5-)-Methyltransferase 3 alpha (DNMT3A))
    Épitope
    • 16
    • 16
    • 12
    • 12
    • 11
    • 8
    • 8
    • 7
    • 7
    • 7
    • 6
    • 6
    • 6
    • 6
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 457-486
    Reactivité
    • 133
    • 49
    • 47
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain, Souris, Rat
    Hôte
    • 124
    • 12
    Lapin
    Clonalité
    • 114
    • 22
    Polyclonal
    Conjugué
    • 58
    • 12
    • 11
    • 11
    • 9
    • 7
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    Cet anticorp DNMT3A est non-conjugé
    Application
    • 106
    • 68
    • 30
    • 27
    • 26
    • 21
    • 13
    • 11
    • 8
    • 6
    • 6
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Homologie
    C
    Purification
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    Immunogène
    This Dnmt3a antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 457-486 amino acids from human Dnmt3a.
    Clone
    RB01852
    Isotype
    Ig Fraction
  • Indications d'application
    WB: 1:1000. WB: 1:1000. WB: 1:1000. WB: 1:1000. IHC-P: 1:50~100
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Date de péremption
    6 months
  • Bing, Zhu, Yu, Li, Liu, Li, Wang, Qi, Guo, Yuan, He, Liu, Liu: "Glucocorticoid-induced S-adenosylmethionine enhances the interferon signaling pathway by restoring STAT1 protein methylation in hepatitis B virus-infected cells." dans: The Journal of biological chemistry, Vol. 289, Issue 47, pp. 32639-55, (2014) (PubMed).

    Siddiqi, Terry, Matushansky: "Hiwi mediated tumorigenesis is associated with DNA hypermethylation." dans: PLoS ONE, Vol. 7, Issue 3, pp. e33711, (2012) (PubMed).

    Koturbash, Zemp, Kolb, Kovalchuk: "Sex-specific radiation-induced microRNAome responses in the hippocampus, cerebellum and frontal cortex in a mouse model." dans: Mutation research, Vol. 722, Issue 2, pp. 114-8, (2011) (PubMed).

    Chen, Wang, Hu, Chang, Liao, Dai, Juo: "OxLDL up-regulates microRNA-29b, leading to epigenetic modifications of MMP-2/MMP-9 genes: a novel mechanism for cardiovascular diseases." dans: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 25, Issue 5, pp. 1718-28, (2011) (PubMed).

    Yamagata, Asada, Tamura, Lee, Maekawa, Taniguchi, Taketani, Matsuoka, Tamura, Sugino: "DNA methyltransferase expression in the human endometrium: down-regulation by progesterone and estrogen." dans: Human reproduction (Oxford, England), Vol. 24, Issue 5, pp. 1126-32, (2009) (PubMed).

    Ishii, Kohu, Yamada, Ishidoya, Kanto, Fuji, Moriya, Satake, Arai: "Up-regulation of DNA-methyltransferase 3A expression is associated with hypomethylation of intron 25 in human testicular germ cell tumors." dans: The Tohoku journal of experimental medicine, Vol. 212, Issue 2, pp. 177-90, (2007) (PubMed).

    Koturbash, Boyko, Rodriguez-Juarez, McDonald, Tryndyak, Kovalchuk, Pogribny, Kovalchuk: "Role of epigenetic effectors in maintenance of the long-term persistent bystander effect in spleen in vivo." dans: Carcinogenesis, Vol. 28, Issue 8, pp. 1831-8, (2007) (PubMed).

    Tryndyak, Muskhelishvili, Kovalchuk, Rodriguez-Juarez, Montgomery, Churchwell, Ross, Beland, Pogribny: "Effect of long-term tamoxifen exposure on genotoxic and epigenetic changes in rat liver: implications for tamoxifen-induced hepatocarcinogenesis." dans: Carcinogenesis, Vol. 27, Issue 8, pp. 1713-20, (2006) (PubMed).

    Koturbash, Rugo, Hendricks, Loree, Thibault, Kutanzi, Pogribny, Yanch, Engelward, Kovalchuk: "Irradiation induces DNA damage and modulates epigenetic effectors in distant bystander tissue in vivo." dans: Oncogene, Vol. 25, Issue 31, pp. 4267-75, (2006) (PubMed).

    Pogribny, Koturbash, Tryndyak, Hudson, Stevenson, Sedelnikova, Bonner, Kovalchuk: "Fractionated low-dose radiation exposure leads to accumulation of DNA damage and profound alterations in DNA and histone methylation in the murine thymus." dans: Molecular cancer research : MCR, Vol. 3, Issue 10, pp. 553-61, (2005) (PubMed).

  • Antigène
    DNMT3A (DNA (Cytosine-5-)-Methyltransferase 3 alpha (DNMT3A))
    Autre désignation
    Dnmt3a (DNMT3A Produits)
    Synonymes
    anticorps DNMT3A, anticorps DNMT3A2, anticorps M.HsaIIIA, anticorps MmuIIIA, anticorps dnmt3a1, anticorps dnmt6, anticorps DNA methyltransferase 3 alpha, anticorps DNA methyltransferase 3A, anticorps DNA (cytosine-5-)-methyltransferase 3 alpha b, anticorps DNMT3A, anticorps Dnmt3a, anticorps dnmt3a, anticorps dnmt3ab
    Sujet
    CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. Dnmt3a is a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated.
    Poids moléculaire
    101858
    ID gène
    1788
    NCBI Accession
    NP_072046, NP_715640, NP_783328, NP_783329
    UniProt
    Q9Y6K1
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