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DNMT3B anticorps (AA 389-417)

DNMT3B Reactivité: Humain WB, IHC (p) Hôte: Lapin Polyclonal RB01906 unconjugated
N° du produit ABIN387884
  • Antigène Voir toutes DNMT3B Anticorps
    DNMT3B (DNA (Cytosine-5-)-Methyltransferase 3 beta (DNMT3B))
    Épitope
    • 18
    • 16
    • 7
    • 7
    • 6
    • 6
    • 5
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 389-417
    Reactivité
    • 87
    • 57
    • 36
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Humain
    Hôte
    • 84
    • 5
    • 2
    • 1
    Lapin
    Clonalité
    • 77
    • 15
    Polyclonal
    Conjugué
    • 37
    • 6
    • 6
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Cet anticorp DNMT3B est non-conjugé
    Application
    • 80
    • 37
    • 29
    • 27
    • 15
    • 13
    • 10
    • 10
    • 2
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Purification
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    Immunogène
    This Dnmt3b antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 389-417 amino acids from human Dnmt3b.
    Clone
    RB01906
    Isotype
    Ig Fraction
    Top Product
    Discover our top product DNMT3B Anticorps primaire
  • Indications d'application
    WB: 1:2000. WB: 1:2000. IHC-P: 1:10~50
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Date de péremption
    6 months
  • Li, Ebert, Li et al.: "T cell receptor (TCR) and transforming growth factor ? (TGF-?) signaling converge on DNA (cytosine-5)-methyltransferase to control forkhead box protein 3 (foxp3) locus methylation and inducible ..." dans: The Journal of biological chemistry, Vol. 288, Issue 26, pp. 19127-39, (2013) (PubMed).

    Chen, Wang, Hu, Chang, Liao, Dai, Juo: "OxLDL up-regulates microRNA-29b, leading to epigenetic modifications of MMP-2/MMP-9 genes: a novel mechanism for cardiovascular diseases." dans: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 25, Issue 5, pp. 1718-28, (2011) (PubMed).

    Sohn, Park, Lee, Yang, Jang, Park, Kim, Lee, Sohn, Kim, Yoo, Choi, Bae, Yeom: "Functional switching of TGF-beta1 signaling in liver cancer via epigenetic modulation of a single CpG site in TTP promoter." dans: Gastroenterology, Vol. 138, Issue 5, pp. 1898-908, (2010) (PubMed).

    Lu, Markowetz, Unwin, Leek, Airoldi, MacArthur, Lachmann, Rozov, Maayan, Boyer, Troyanskaya, Whetton, Lemischka: "Systems-level dynamic analyses of fate change in murine embryonic stem cells." dans: Nature, Vol. 462, Issue 7271, pp. 358-62, (2009) (PubMed).

    Yamagata, Asada, Tamura, Lee, Maekawa, Taniguchi, Taketani, Matsuoka, Tamura, Sugino: "DNA methyltransferase expression in the human endometrium: down-regulation by progesterone and estrogen." dans: Human reproduction (Oxford, England), Vol. 24, Issue 5, pp. 1126-32, (2009) (PubMed).

    Park, Sohn, Yu, Suh, Chung, Lee, Surzycki, Lee: "Aberrant epigenetic modifications in hepatocarcinogenesis induced by hepatitis B virus X protein." dans: Gastroenterology, Vol. 132, Issue 4, pp. 1476-94, (2007) (PubMed).

    Fabbri, Garzon, Cimmino, Liu, Zanesi, Callegari, Liu, Alder, Costinean, Fernandez-Cymering, Volinia, Guler, Morrison, Chan, Marcucci, Calin, Huebner, Croce: "MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, Issue 40, pp. 15805-10, (2007) (PubMed).

    Koturbash, Boyko, Rodriguez-Juarez, McDonald, Tryndyak, Kovalchuk, Pogribny, Kovalchuk: "Role of epigenetic effectors in maintenance of the long-term persistent bystander effect in spleen in vivo." dans: Carcinogenesis, Vol. 28, Issue 8, pp. 1831-8, (2007) (PubMed).

    Tryndyak, Muskhelishvili, Kovalchuk, Rodriguez-Juarez, Montgomery, Churchwell, Ross, Beland, Pogribny: "Effect of long-term tamoxifen exposure on genotoxic and epigenetic changes in rat liver: implications for tamoxifen-induced hepatocarcinogenesis." dans: Carcinogenesis, Vol. 27, Issue 8, pp. 1713-20, (2006) (PubMed).

    Koturbash, Rugo, Hendricks, Loree, Thibault, Kutanzi, Pogribny, Yanch, Engelward, Kovalchuk: "Irradiation induces DNA damage and modulates epigenetic effectors in distant bystander tissue in vivo." dans: Oncogene, Vol. 25, Issue 31, pp. 4267-75, (2006) (PubMed).

    Brueckner, Garcia Boy, Siedlecki, Musch, Kliem, Zielenkiewicz, Suhai, Wiessler, Lyko: "Epigenetic reactivation of tumor suppressor genes by a novel small-molecule inhibitor of human DNA methyltransferases." dans: Cancer research, Vol. 65, Issue 14, pp. 6305-11, (2005) (PubMed).

    Pogribny, Koturbash, Tryndyak, Hudson, Stevenson, Sedelnikova, Bonner, Kovalchuk: "Fractionated low-dose radiation exposure leads to accumulation of DNA damage and profound alterations in DNA and histone methylation in the murine thymus." dans: Molecular cancer research : MCR, Vol. 3, Issue 10, pp. 553-61, (2005) (PubMed).

  • Antigène
    DNMT3B (DNA (Cytosine-5-)-Methyltransferase 3 beta (DNMT3B))
    Autre désignation
    Dnmt3b (DNMT3B Produits)
    Synonymes
    anticorps DNMT3B, anticorps LOC100218113, anticorps ICF, anticorps ICF1, anticorps M.HsaIIIB, anticorps MmuIIIB, anticorps cb91, anticorps dnmt3bl, anticorps dnmt7, anticorps sb:cb91, anticorps wu:fb16h07, anticorps DNA methyltransferase 3 beta, anticorps DNA methyltransferase 3B, anticorps DNA (cytosine-5-)-methyltransferase 3 beta, duplicate a, anticorps DNMT3B, anticorps Dnmt3b, anticorps dnmt3b, anticorps dnmt3ba
    Sujet
    CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. Dnmt3b is a DNA methyltransferase which is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes primarily to the nucleus and its expression is developmentally regulated. Mutations in this gene cause the immunodeficiency-centromeric instability-facial anomalies (ICF)syndrome.
    Poids moléculaire
    95751
    ID gène
    1789
    NCBI Accession
    NP_001193984, NP_001193985, NP_008823, NP_787044, NP_787045, NP_787046
    UniProt
    Q9UBC3
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