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SET7 anticorps (C-Term)

SETD8P1 Reactivité: Humain WB Hôte: Lapin Polyclonal RB5744 unconjugated
N° du produit ABIN387998
  • Antigène Voir toutes SET7 (SETD8P1) Anticorps
    SET7 (SETD8P1) (SET Domain Containing 8 Pseudogene 1 (SETD8P1))
    Épitope
    • 6
    • 5
    • 5
    • 2
    • 1
    AA 289-317, C-Term
    Reactivité
    • 15
    • 2
    Humain
    Hôte
    • 14
    • 1
    Lapin
    Clonalité
    • 14
    • 1
    Polyclonal
    Conjugué
    • 5
    • 2
    • 2
    • 2
    • 2
    • 2
    Cet anticorp SET7 est non-conjugé
    Application
    • 14
    • 12
    • 7
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Purification
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    Immunogène
    This SET7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 289-317 amino acids from the C-terminal region of human SET7.
    Clone
    RB5744
    Isotype
    Ig Fraction
    Top Product
    Discover our top product SETD8P1 Anticorps primaire
  • Indications d'application
    WB: 1:1000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Date de péremption
    6 months
  • Antigène
    SET7 (SETD8P1) (SET Domain Containing 8 Pseudogene 1 (SETD8P1))
    Autre désignation
    SET7 (SETD8P1 Produits)
    Synonymes
    anticorps KMT7, anticorps SET7, anticorps SET7/9, anticorps SET9, anticorps 1600028F23Rik, anticorps H3K4MT, anticorps Set7, anticorps Set7/9, anticorps mKIAA1717, anticorps SET domain containing lysine methyltransferase 7, anticorps SET domain containing (lysine methyltransferase) 7, anticorps SETD7, anticorps Setd7
    Sujet
    Histone methyltransferases (HMTases) selectively methylate evolutionarily conserved arginine or lysine residues, primarily in the N-terminal tails of histones H3 and H4. Signal transduction pathways affecting the N-terminal tails of histones lead to a number of post-translational modifications including acetylation, phosphorylation, poly(ADP-ribosylation), ubiquitination and methylation. These modifications play critical roles in regulating chromatin structure and gene expression. Set7/9 is a histone specific HMTase that methylates histone H3 lysine 4. Set7/9 transfers methyl groups to lysine 4 of histone H3 in complex with S-adenosyl-L-methionine. In yeast, H4-K20 methylation does not have any apparent role in the regulation of gene expression or heterochromatin function, rather it appears to play a role in DNA damage response. Loss of Set9 activity or mutation of H4-K20 markedly impairs yeast cell survival after genotoxic challenge and compromises the ability of cells to maintain checkpoint mediated cell cycle arrest. Genetic experiments link Set9 to Crb2, a homolog of the mammalian checkpoint protein 53BP1, and the enzyme is required for Crb2 localization to sites of DNA damage.
    Poids moléculaire
    40721
    ID gène
    80854
    NCBI Accession
    NP_085151
    UniProt
    Q8WTS6
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