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SUMO2/3 anticorps (C-Term)

SUMO2/3 Reactivité: Humain, Souris, Rat WB, IF, IHC (p) Hôte: Lapin Polyclonal RB00635 unconjugated
N° du produit ABIN388034
  • Antigène Tous les produits SUMO2/3
    SUMO2/3 (Small Ubiquitin Related Modifier 2/3 (SUMO2/3))
    Épitope
    • 16
    • 7
    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 49-81, C-Term
    Reactivité
    • 49
    • 14
    • 14
    • 1
    • 1
    • 1
    Humain, Souris, Rat
    Hôte
    • 38
    • 10
    • 1
    Lapin
    Clonalité
    • 30
    • 19
    Polyclonal
    Conjugué
    • 15
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp SUMO2/3 est non-conjugé
    Application
    • 42
    • 24
    • 15
    • 15
    • 14
    • 13
    • 10
    • 7
    • 4
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Homologie
    X, Zf, B, C, Ha, Pr, Pig
    Purification
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogène
    This SUMO2/3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 49-81 amino acids from the C-terminal region of human SUMO2/3.
    Clone
    RB00635
    Isotype
    IgG
  • Indications d'application
    IF: 1:100. IF: 1:100. WB: 1:2000. IHC-P: 1:50~100
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Date de péremption
    6 months
  • Higginbotham, OShea: "Adenovirus E4-ORF3 Targets PIAS3 and Together with E1B-55K Remodels SUMO Interactions in the Nucleus and at Virus Genome Replication Domains." dans: Journal of virology, Vol. 89, Issue 20, pp. 10260-72, (2015) (PubMed).

    Myles, Fontecilla, Valdez, Vithayathil, Naik, Belkaid, Ouyang, Datta: "Signaling via the IL-20 receptor inhibits cutaneous production of IL-1β and IL-17A to promote infection with methicillin-resistant Staphylococcus aureus." dans: Nature immunology, Vol. 14, Issue 8, pp. 804-11, (2013) (PubMed).

    Heo, Lee, Nigro, Thomas, Le, Chang, McClain, Reinhart-King, King, Berk, Fujiwara, Woo, Abe: "PKC? mediates disturbed flow-induced endothelial apoptosis via p53 SUMOylation." dans: The Journal of cell biology, Vol. 193, Issue 5, pp. 867-84, (2011) (PubMed).

    Nadtochiy, Redman, Rahman, Brookes: "Lysine deacetylation in ischaemic preconditioning: the role of SIRT1." dans: Cardiovascular research, Vol. 89, Issue 3, pp. 643-9, (2011) (PubMed).

    Snider, Weerasinghe, Iñiguez-Lluhí, Herrmann, Omary: "Keratin hypersumoylation alters filament dynamics and is a marker for human liver disease and keratin mutation." dans: The Journal of biological chemistry, Vol. 286, Issue 3, pp. 2273-84, (2011) (PubMed).

    Cho, Yi, Tserentsoodol, Searle, Ferreira: "Neuroprotection resulting from insufficiency of RANBP2 is associated with the modulation of protein and lipid homeostasis of functionally diverse but linked pathways in response to oxidative stress." dans: Disease models & mechanisms, Vol. 3, Issue 9-10, pp. 595-604, (2010) (PubMed).

    Martin, Schwamborn, Urlaub, Gan, Guan, Dejean: "Spatial interplay between PIASy and FIP200 in the regulation of signal transduction and transcriptional activity." dans: Molecular and cellular biology, Vol. 28, Issue 8, pp. 2771-81, (2008) (PubMed).

    Degerny, Monte, Beaudoin, Jaffray, Portois, Hay, de Launoit, Baert: "SUMO modification of the Ets-related transcription factor ERM inhibits its transcriptional activity." dans: The Journal of biological chemistry, Vol. 280, Issue 26, pp. 24330-8, (2005) (PubMed).

  • Antigène
    SUMO2/3 (Small Ubiquitin Related Modifier 2/3 (SUMO2/3))
    Autre désignation
    SUMO2/3 (SUMO2/3 Produits)
    Synonymes
    anticorps SUMO2, anticorps small ubiquitin-like modifier 2, anticorps SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae)-like, anticorps small ubiquitin-related modifier 2, anticorps SUMO2, anticorps LOC711990, anticorps LOC714892
    Sujet
    SUMO2 and SUMO3 are members of the SUMO (small ubiquitin-like modifier) protein family. This protein family functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational modification system. However, unlike ubiquitin which targets proteins for degradation, this protein is involved in a variety of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability. In vertebrates, three members of the SUMO family have been described, SUMO 1 and the functionally distinct homologues SUMO 2 and SUMO 3. SUMO modification sites present in the N terminal regions of SUMO 2 and SUMO 3 are utilized by SAE1/SAE2 (SUMO E1) and Ubc9 (SUMO E2) to form polymeric chains of SUMO 2 and SUMO 3 on protein substrates, a property not shared by SUMO 1.
    Poids moléculaire
    11637
    ID gène
    6612
    NCBI Accession
    NP_008867
    UniProt
    P55854
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