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CBLC anticorps (N-Term)

CBLC Reactivité: Humain WB, IHC (p) Hôte: Lapin Polyclonal RB0694 unconjugated
N° du produit ABIN388071
  • Antigène Voir toutes CBLC Anticorps
    CBLC (Cbl proto-oncogene C (CBLC))
    Épitope
    • 10
    • 7
    • 7
    • 6
    • 5
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    AA 1-30, N-Term
    Reactivité
    • 46
    • 2
    • 1
    Humain
    Hôte
    • 41
    • 5
    Lapin
    Clonalité
    • 41
    • 5
    Polyclonal
    Conjugué
    • 26
    • 4
    • 4
    • 4
    • 4
    • 4
    Cet anticorp CBLC est non-conjugé
    Application
    • 45
    • 34
    • 29
    • 6
    • 5
    • 5
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Purification
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    Immunogène
    This CBLC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human CBLC.
    Clone
    RB0694
    Isotype
    Ig Fraction
    Top Product
    Discover our top product CBLC Anticorps primaire
  • Indications d'application
    WB: 1:1000. IHC-P: 1:50~100
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Date de péremption
    6 months
  • Antigène
    CBLC (Cbl proto-oncogene C (CBLC))
    Autre désignation
    CBLC (CBLC Produits)
    Synonymes
    anticorps CBL-3, anticorps CBL-SL, anticorps RNF57, anticorps Cbl proto-oncogene C, anticorps CBLC, anticorps Cblc
    Sujet
    CBLC proteins are a family of ubiquitin protein ligases (E3s) that negatively regulate signaling by targeting activated tyrosine kinases for degradation. Cbl- c is the most recently cloned member of the Cbl proteins and is expressed only in epithelial cells (the other Cbl proteins are ubiquitously expressed). Cbl-c, like the other mammalian Cbl proteins, can ubiquitinate the activated EGFR and target it for degradation. Through interactions with proteins containing SRC homology-2 (SH2) and SH3 domains, CBL proteins modulate downstream cell signaling.
    Poids moléculaire
    52456
    ID gène
    23624
    NCBI Accession
    NP_001124324, NP_036248
    UniProt
    Q9ULV8
    Pathways
    EGFR Signaling Pathway
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