HGF anticorps (C-Term)

N° du produit ABIN388462

Détail du produit anti-HGF anticorps

Antigène: HGF (Hepatocyte Growth Factor (Hepapoietin A, Scatter Factor) (HGF))

Épitope: AA 521-554, C-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HGF est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogène: This HGF antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 521-554 amino acids from the C-terminal region of human HGF.

Clone: RB09924

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000. IHC-P: 1:50~100. FC: 1:10~50

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 6 months

Références pour anticorps anti-HGF (ABIN388462)

Phan, Fuentes-Mattei, Wu, Velazquez-Torres, Sircar, Wood, Hai, Jimenez, Cote, Ozsari, Hofmann, Zheng, Verhaak, Pagliaro, Cortez, Lee, Yeung, Habra: "Hepatocyte Growth Factor/cMET Pathway Activation Enhances Cancer Hallmarks in Adrenocortical Carcinoma." dans: Cancer research, Vol. 75, Issue 19, pp. 4131-42, (2015) (PubMed).

Vogel, Chatterjee, Metzger, Borst, Geisler, Seizer, Müller, Mack, Schumann, Bhring, Lang, Sorg, Langer, Gawaz et al.: "Activated platelets interfere with recruitment of mesenchymal stem cells to apoptotic cardiac cells via high mobility group box 1/Toll-like receptor 4-mediated down-regulation of hepatocyte growth ..." dans: The Journal of biological chemistry, Vol. 289, Issue 16, pp. 11068-82, (2014) (PubMed).

Détails sur HGF

Antigène: HGF (Hepatocyte Growth Factor (Hepapoietin A, Scatter Factor) (HGF))

Autre désignation: HGF (HGF Produits)

Synonymes: anticorps DFNB39, anticorps F-TCF, anticorps HGFB, anticorps HPTA, anticorps SF, anticorps HGF, anticorps C230052L06Rik, anticorps HGF/SF, anticorps NK1, anticorps NK2, anticorps SF/HGF, anticorps hepatocyte growth factor, anticorps HGF, anticorps Hgf

Sujet: Hepatocyte growth factor regulates cell growth, cell motility, and morphogenesis by activating a tyrosine kinase signaling cascade after binding to the proto-oncogenic c-Met receptor. Hepatocyte growth factor is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. Its ability to stimulate mitogenesis, cell motility, and matrix invasion gives it a central role in angiogenesis, tumorogenesis, and tissue regeneration. It is secreted as a single inactive polypeptide and is cleaved by serine proteases into a 69- kDa alpha-chain and 34- kDa beta-chain. A disulfide bond between the alpha and beta chains produces the active, heterodimeric molecule. The protein belongs to the plasminogen subfamily of S1 peptidases but has no detectable protease activity. Alternative splicing of this gene produces multiple transcript variants encoding different isoforms. Transcript Variant: This variant (1) encodes the longest isoform (1). To date, experimental evidence for cleavage of the proprotein into two mature chains has been shown only for isoform 1.

Poids moléculaire: 83134

ID gène: 3082

NCBI Accession: NP_000592, NP_001010931, NP_001010932, NP_001010933, NP_001010934

UniProt: P14210

Pathways: Signalisation RTK, Carbohydrate Homeostasis, Glycosaminoglycan Metabolic Process, Synaptic Membrane, Signaling of Hepatocyte Growth Factor Receptor