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MAP1LC3A anticorps

MAP1LC3A Reactivité: Humain WB, IF Hôte: Lapin Polyclonal RB7993 unconjugated
N° du produit ABIN388463
  • Antigène Voir toutes MAP1LC3A Anticorps
    MAP1LC3A (Microtubule-Associated Protein 1 Light Chain 3 alpha (MAP1LC3A))
    Reactivité
    • 213
    • 106
    • 87
    • 12
    • 9
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 175
    • 44
    • 2
    Lapin
    Clonalité
    • 166
    • 55
    Polyclonal
    Conjugué
    • 110
    • 18
    • 15
    • 14
    • 14
    • 13
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    Cet anticorp MAP1LC3A est non-conjugé
    Application
    • 199
    • 95
    • 74
    • 47
    • 33
    • 32
    • 29
    • 14
    • 14
    • 14
    • 11
    • 10
    • 9
    • 6
    • 5
    Western Blotting (WB), Immunofluorescence (IF)
    Purification
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    Immunogène
    This LC3 antibody is generated from rabbits immunized with full-length recombinant human LC3 (APG8a).
    Clone
    RB7993
    Isotype
    Ig Fraction
    Top Product
    Discover our top product MAP1LC3A Anticorps primaire
  • Indications d'application
    IF: 1:200. WB: 1:1000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Date de péremption
    6 months
  • Want, Gillespie, Wang, Gordon, Iomini, Ritch, Wolosin, Bernstein: "Autophagy and Mitochondrial Dysfunction in Tenon Fibroblasts from Exfoliation Glaucoma Patients." dans: PLoS ONE, Vol. 11, Issue 7, pp. e0157404, (2017) (PubMed).

    Hu, Wu, Ding, Zhang: "Thrombin preferentially induces autophagy in glia cells in the rat central nervous system." dans: Neuroscience letters, Vol. 630, pp. 53-58, (2017) (PubMed).

    Wu, Hong, Wang, Huang, Yeh, Wang, Wang, Chiu: "A novel histone deacetylase inhibitor TMU-35435 enhances etoposide cytotoxicity through the proteasomal degradation of DNA-PKcs in triple-negative breast cancer." dans: Cancer letters, Vol. 400, pp. 79-88, (2017) (PubMed).

    Islam, Shin, Yun, Cho, Seo, Chae, Cho: "The effect of RNAi silencing of p62 using an osmotic polysorbitol transporter on autophagy and tumorigenesis in lungs of K-rasLA1 mice." dans: Biomaterials, Vol. 35, Issue 5, pp. 1584-96, (2013) (PubMed).

    Liu, Jia, Zhang, Hou, Wang, Hao, Ruan, Yu, Zheng: "Involvement of melatonin in autophagy-mediated mouse hepatoma H22 cell survival." dans: International immunopharmacology, Vol. 12, Issue 2, pp. 394-401, (2012) (PubMed).

    Zhang, Morgan, Chen, Choksi, Liu: "Induction of autophagy is essential for monocyte-macrophage differentiation." dans: Blood, Vol. 119, Issue 12, pp. 2895-905, (2012) (PubMed).

    Wojtkowiak, Sane, Kleinman, Sloane, Reiners, Mattingly: "Aborted autophagy and nonapoptotic death induced by farnesyl transferase inhibitor and lovastatin." dans: The Journal of pharmacology and experimental therapeutics, Vol. 337, Issue 1, pp. 65-74, (2011) (PubMed).

    Mizuno, Yasuo, Bogaard, Kraskauskas, Natarajan, Voelkel: "Inhibition of histone deacetylase causes emphysema." dans: American journal of physiology. Lung cellular and molecular physiology, Vol. 300, Issue 3, pp. L402-13, (2011) (PubMed).

    Zheng, Liu, Li, Xu, Xu: "RNA interference-mediated downregulation of Beclin1 attenuates cerebral ischemic injury in rats." dans: Acta pharmacologica Sinica, Vol. 30, Issue 7, pp. 919-27, (2009) (PubMed).

  • Antigène
    MAP1LC3A (Microtubule-Associated Protein 1 Light Chain 3 alpha (MAP1LC3A))
    Autre désignation
    LC3 (MAP1LC3A Produits)
    Synonymes
    anticorps ATG8E, anticorps LC3, anticorps LC3A, anticorps MAP1ALC3, anticorps MAP1BLC3, anticorps 1010001H21Rik, anticorps 4922501H04Rik, anticorps LC3a, anticorps MGC69006, anticorps zgc:77094, anticorps MGC89867, anticorps MAP1LC3A, anticorps map1lc3a, anticorps microtubule associated protein 1 light chain 3 alpha, anticorps microtubule-associated protein 1 light chain 3 alpha, anticorps microtubule associated protein 1 light chain 3 alpha S homeolog, anticorps MAP1LC3A, anticorps Map1lc3a, anticorps map1lc3a.S, anticorps map1lc3a
    Sujet
    Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole). MAP1A and MAP1B are microtubule-associated proteins which mediate the physical interactions between microtubules and components of the cytoskeleton. These proteins are involved in formation of autophagosomal vacuoles (autophagosomes). MAP1A and MAP1B each consist of a heavy chain subunit and multiple light chain subunits. MAP1LC3a is one of the light chain subunits and can associate with either MAP1A or MAP1B. The precursor molecule is cleaved by APG4B/ATG4B to form the cytosolic form, LC3-I. This is activated by APG7L/ATG7, transferred to ATG3 and conjugated to phospholipid to form the membrane-bound form, LC3-II.
    ID gène
    84557
    NCBI Accession
    NP_115903, NP_852610
    UniProt
    Q9H492, Q9GZQ8
    Pathways
    Autophagy
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