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ATG4A anticorps (AA 1-30)

ATG4A Reactivité: Humain, Souris WB, IHC (p) Hôte: Lapin Polyclonal RB7493 unconjugated
N° du produit ABIN388491
  • Antigène Voir toutes ATG4A Anticorps
    ATG4A (Autophagy related 4A Cysteine Peptidase (ATG4A))
    Épitope
    • 15
    • 11
    • 11
    • 6
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-30
    Reactivité
    • 68
    • 28
    • 22
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    Humain, Souris
    Hôte
    • 61
    • 4
    • 2
    • 1
    Lapin
    Clonalité
    • 64
    • 4
    Polyclonal
    Conjugué
    • 30
    • 5
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp ATG4A est non-conjugé
    Application
    • 45
    • 27
    • 25
    • 20
    • 14
    • 13
    • 9
    • 7
    • 5
    • 3
    • 2
    • 2
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Purification
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogène
    This ATG4A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from human ATG4A.
    Clone
    RB7493
    Isotype
    Ig Fraction
    Top Product
    Discover our top product ATG4A Anticorps primaire
  • Indications d'application
    WB: 1:1000. IHC-P: 1:50~100
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Date de péremption
    6 months
  • Antigène
    ATG4A (Autophagy related 4A Cysteine Peptidase (ATG4A))
    Autre désignation
    ATG4A (ATG4A Produits)
    Synonymes
    anticorps apg4a, anticorps autl2, anticorps F6E13.27, anticorps APG4A, anticorps zgc:111958, anticorps Aut2a, anticorps AUTL2, anticorps AI627006, anticorps AV169859, anticorps Apg4a, anticorps Atg4al, anticorps Autl2, anticorps Atg4a, anticorps autophagy related 4A cysteine peptidase L homeolog, anticorps autophagy related 4A cysteine peptidase, anticorps Peptidase family C54 protein, anticorps ATG4 autophagy related 4 homolog A (S. cerevisiae), anticorps autophagy related 4A, cysteine peptidase, anticorps atg4a.L, anticorps ATG4A, anticorps AT2G44140, anticorps atg4a, anticorps Atg4a
    Sujet
    Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole). APG4A is a cysteine protease required for autophagy, which cleaves the C-terminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes. Preferred substrate is GABARAPL2 followed by MAP1LC3A and GABARAP.
    Poids moléculaire
    45378
    ID gène
    115201
    NCBI Accession
    NP_443168, NP_840054
    UniProt
    Q8WYN0
    Pathways
    Autophagy
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