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ATG7 anticorps (C-Term)

ATG7 Reactivité: Humain, Souris WB, IF, IHC (p) Hôte: Lapin Polyclonal RB7474 unconjugated
N° du produit ABIN388523
  • Antigène Voir toutes ATG7 Anticorps
    ATG7 (ATG7 Autophagy Related 7 (ATG7))
    Épitope
    • 21
    • 16
    • 15
    • 9
    • 7
    • 7
    • 6
    • 6
    • 5
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 540-569, C-Term
    Reactivité
    • 128
    • 39
    • 28
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain, Souris
    Hôte
    • 115
    • 14
    • 2
    Lapin
    Clonalité
    • 108
    • 23
    Polyclonal
    Conjugué
    • 63
    • 9
    • 9
    • 8
    • 6
    • 6
    • 5
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp ATG7 est non-conjugé
    Application
    • 109
    • 66
    • 50
    • 25
    • 18
    • 16
    • 14
    • 13
    • 13
    • 9
    • 5
    • 4
    • 3
    • 2
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Homologie
    C, Rat
    Purification
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogène
    This ATG7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 540-569 amino acids from the C-terminal region of human ATG7.
    Clone
    RB7474
    Isotype
    Ig Fraction
  • Indications d'application
    IF: 1:25. WB: 1:1000. WB: 1:1000. WB: 1:500. IHC-P-Leica: 1:1000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Date de péremption
    6 months
  • Wu, Sun, Ma, Zhu, Zhang, Pan, Li, Liu, Diao, Li: "A C-terminally truncated mouse Best3 splice variant targets and alters the ion balance in lysosome-endosome hybrids and the endoplasmic reticulum." dans: Scientific reports, Vol. 6, pp. 27332, (2018) (PubMed).

    Ding, Shi, Zhou, Qiu, Xu, Dai, Shi, Wang, Ke, Wu, Fan: "Association of autophagy defect with a malignant phenotype and poor prognosis of hepatocellular carcinoma." dans: Cancer research, Vol. 68, Issue 22, pp. 9167-75, (2008) (PubMed).

  • Antigène
    ATG7 (ATG7 Autophagy Related 7 (ATG7))
    Autre désignation
    ATG7 (ATG7 Produits)
    Synonymes
    anticorps APG7-LIKE, anticorps APG7L, anticorps GSA7, anticorps D8, anticorps UBA1B, anticorps UBE1L, anticorps UBE2, anticorps Ube1l, anticorps 1300004C08Rik, anticorps AO090001000744, anticorps atg7, anticorps 1810013K23Rik, anticorps Agp7, anticorps Apg7l, anticorps Atg7l, anticorps ATAPG7, anticorps ATATG7, anticorps ATG7, anticorps AUTOPHAGY 7, anticorps AUTOPHAGY-RELATED 7, anticorps K15I22.10, anticorps K15I22_10, anticorps autophagy related 7, anticorps ubiquitin like modifier activating enzyme 7, anticorps ubiquitin-like modifier activating enzyme 7, anticorps autophagy-related protein 7, anticorps Autophagy-related protein 7, anticorps Apg7p, anticorps ThiF family protein, anticorps ubiquitin-like conjugating enzyme Atg7, anticorps ATG7, anticorps UBA7, anticorps Uba7, anticorps ANI_1_3368024, anticorps AOR_1_1338164, anticorps PTRG_02236, anticorps PAAG_00287, anticorps PITG_12537, anticorps atg7, anticorps Atg7, anticorps APG7
    Sujet
    Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole). APG7 functions as an E1 enzyme essential for multisubstrates such as GABARAPL1 and ATG12. APG3L is an E2-like conjugating enzyme facilitating covalent binding of APG8 (MAP1LC3) to phosphatidylethanolamine (PE). APG7 (an E1-like enzyme) facilitates this reaction by forming an E1-E2 complex with APG3. Formation of the PE conjugate is essential for autophagy.
    Poids moléculaire
    77960
    ID gène
    10533
    NCBI Accession
    NP_001129503, NP_001138384, NP_006386
    UniProt
    O95352
    Pathways
    Response to Water Deprivation, Autophagy
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