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Beclin 1 anticorps (AA 181-210)

BECN1 Reactivité: Humain, Souris WB, IHC (p) Hôte: Lapin Polyclonal RB7461 unconjugated
N° du produit ABIN388545
  • Antigène Voir toutes Beclin 1 (BECN1) Anticorps
    Beclin 1 (BECN1) (Beclin 1, Autophagy Related (BECN1))
    Épitope
    • 16
    • 15
    • 15
    • 9
    • 9
    • 9
    • 8
    • 8
    • 8
    • 8
    • 8
    • 7
    • 7
    • 6
    • 6
    • 6
    • 6
    • 6
    • 6
    • 6
    • 6
    • 6
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 181-210
    Reactivité
    • 204
    • 89
    • 74
    • 10
    • 9
    • 7
    • 7
    • 5
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Humain, Souris
    Hôte
    • 171
    • 36
    • 2
    Lapin
    Clonalité
    • 170
    • 39
    Polyclonal
    Conjugué
    • 93
    • 18
    • 16
    • 15
    • 14
    • 14
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp Beclin 1 est non-conjugé
    Application
    • 149
    • 99
    • 61
    • 38
    • 33
    • 26
    • 26
    • 22
    • 20
    • 13
    • 13
    • 4
    • 4
    • 2
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Homologie
    B, C
    Purification
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    Immunogène
    This Beclin 1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 181-210 amino acids from human Beclin 1.
    Clone
    RB7461
    Isotype
    Ig Fraction
    Top Product
    Discover our top product BECN1 Anticorps primaire
  • Indications d'application
    WB: 1:1000. WB: 1:1000. IHC-P: 1:50~100
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Date de péremption
    6 months
  • Li, Zhou, Yang, Li, Zhang, Zheng: "Curcumin induces apoptotic cell death and protective autophagy in human gastric cancer cells." dans: Oncology reports, Vol. 37, Issue 6, pp. 3459-3466, (2018) (PubMed).

    Zhang, Yi, Ko, Kim, Seo, Lee, Lee, Kim: "Expression of LC3 and Beclin 1 in the spinal dorsal horn following spinal nerve ligation-induced neuropathic pain." dans: Brain research, Vol. 1519, pp. 31-9, (2013) (PubMed).

    Liu, He, von Rütte, Yousefi, Hunger, Simon: "Down-regulation of autophagy-related protein 5 (ATG5) contributes to the pathogenesis of early-stage cutaneous melanoma." dans: Science translational medicine, Vol. 5, Issue 202, pp. 202ra123, (2013) (PubMed).

    Thyagarajan, Jedinak, Nguyen, Terry, Baldridge, Jiang, Sliva: "Triterpenes from Ganoderma Lucidum induce autophagy in colon cancer through the inhibition of p38 mitogen-activated kinase (p38 MAPK)." dans: Nutrition and cancer, Vol. 62, Issue 5, pp. 630-40, (2010) (PubMed).

    Bohensky, Leshinsky, Srinivas, Shapiro: "Chondrocyte autophagy is stimulated by HIF-1 dependent AMPK activation and mTOR suppression." dans: Pediatric nephrology (Berlin, Germany), Vol. 25, Issue 4, pp. 633-42, (2010) (PubMed).

  • Antigène
    Beclin 1 (BECN1) (Beclin 1, Autophagy Related (BECN1))
    Autre désignation
    Beclin 1 (BECN1 Produits)
    Sujet
    Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole). Beclin 1 plays a role in two fundamentally important cell biological pathways: autophagy and apoptosis. Beclin 1 is thought to function as a VPS and autophagy protein as part of a complex with Class III PI3 kinase, Vps34.
    Poids moléculaire
    51896
    ID gène
    8678
    NCBI Accession
    NP_003757
    UniProt
    Q14457
    Pathways
    Autophagy
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