GABARAP anticorps (AA 1-30)

N° du produit ABIN388564

Détail du produit anti-GABARAP anticorps

Antigène: GABARAP (GABA(A) Receptor-Associated Protein (GABARAP))

Épitope: AA 1-30

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GABARAP est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Homologie: B, Rb

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This GABARAP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids of human GABARAP.

Clone: RB11846

Isotype: IgG

Information d'application

Indications d'application: IF: 1:25. IF: 1:25. WB: 1:1000-1 :2000. IHC-P: 1:25. IHC-P: 1:25

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 6 months

Références pour anticorps anti-GABARAP (ABIN388564)

Joachim, Razi, Judith, Wirth, Calamita, Encheva, Dynlacht, Snijders, OReilly, Jefferies, Tooze: "Centriolar Satellites Control GABARAP Ubiquitination and GABARAP-Mediated Autophagy." dans: Current biology : CB, Vol. 27, Issue 14, pp. 2123-2136.e7, (2018) (PubMed).

Clough, Wright, Pereira, Hirst, Johnston, Henriques, Frickel: "K63-Linked Ubiquitination Targets Toxoplasma gondii for Endo-lysosomal Destruction in IFNγ-Stimulated Human Cells." dans: PLoS pathogens, Vol. 12, Issue 11, pp. e1006027, (2017) (PubMed).

Egan, Chun, Vamos, Zou, Rong, Miller, Lou, Raveendra-Panickar, Yang, Sheffler, Teriete, Asara, Turk, Cosford, Shaw: "Small Molecule Inhibition of the Autophagy Kinase ULK1 and Identification of ULK1 Substrates." dans: Molecular cell, Vol. 59, Issue 2, pp. 285-97, (2015) (PubMed).

Orfali, ODonovan, Nyhan, Britschgi, Tschan, Cahill, Mongan, Gudas, McKenna: "Induction of autophagy is a key component of all-trans-retinoic acid-induced differentiation in leukemia cells and a potential target for pharmacologic modulation." dans: Experimental hematology, Vol. 43, Issue 9, pp. 781-93.e2, (2015) (PubMed).

Détails sur GABARAP

Antigène: GABARAP (GABA(A) Receptor-Associated Protein (GABARAP))

Autre désignation: GABARAP (GABARAP Produits)

Synonymes: anticorps GABARAP, anticorps ATG8A, anticorps GABARAP-a, anticorps MM46, anticorps gabarap, anticorps mg:bb02b03, anticorps GABA type A receptor-associated protein, anticorps gamma-aminobutyric acid receptor-associated protein, anticorps GABA(A) receptor-associated protein a, anticorps gamma-aminobutyric acid receptor associated protein, anticorps GABARAP, anticorps LOC5568843, anticorps Gabarap, anticorps gabarapa

Sujet: Gamma-aminobutyric acid A receptors [GABA(A) receptors] are ligand-gated chloride channels that mediate inhibitory neurotransmission. GABARAP is GABA(A) receptor-associated protein, which is highly positively charged in its N-terminus and shares sequence similarity with light chain-3 of microtubule-associated proteins 1A and 1B. This protein clusters neurotransmitter receptors by mediating interaction with the cytoskeleton.

Poids moléculaire: 13918

ID gène: 11337

NCBI Accession: NP_009209

UniProt: O95166

Pathways: Autophagy