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UVRAG anticorps (C-Term)

UVRAG Reactivité: Humain, Souris WB, IF, IHC (p) Hôte: Lapin Polyclonal RB10849 unconjugated
N° du produit ABIN388586
  • Antigène Voir toutes UVRAG Anticorps
    UVRAG (UV Radiation Resistance Associated Gene (UVRAG))
    Épitope
    • 14
    • 9
    • 6
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 666-699, C-Term
    Reactivité
    • 63
    • 37
    • 30
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain, Souris
    Hôte
    • 59
    • 4
    Lapin
    Clonalité
    • 61
    • 2
    Polyclonal
    Conjugué
    • 26
    • 5
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp UVRAG est non-conjugé
    Application
    • 56
    • 21
    • 13
    • 12
    • 11
    • 11
    • 9
    • 9
    • 6
    • 2
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Purification
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    Immunogène
    This UVRAG antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 666-699 amino acids from the C-terminal region of human UVRAG.
    Clone
    RB10849
    Isotype
    Ig Fraction
    Top Product
    Discover our top product UVRAG Anticorps primaire
  • Indications d'application
    IF: 1:10~50. IF: 1:200. WB: 1:1000. IHC-P: 1:50~100
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Date de péremption
    6 months
  • Armstrong, Corazzari, Martin, Pagliarini, Falasca, Hill, Ellis, Al Sabah, Redfern, Fimia, Piacentini, Lovat: "Oncogenic B-RAF signaling in melanoma impairs the therapeutic advantage of autophagy inhibition." dans: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 17, Issue 8, pp. 2216-26, (2011) (PubMed).

    Sun, Zhang, Fan, Wong, Ding, Chen, Zhong: "The RUN domain of rubicon is important for hVps34 binding, lipid kinase inhibition, and autophagy suppression." dans: The Journal of biological chemistry, Vol. 286, Issue 1, pp. 185-91, (2011) (PubMed).

    Neely, Green, LaFerla: "Presenilin is necessary for efficient proteolysis through the autophagy-lysosome system in a ?-secretase-independent manner." dans: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 31, Issue 8, pp. 2781-91, (2011) (PubMed).

    Sun, Westphal, Wong, Tan, Zhong: "Rubicon controls endosome maturation as a Rab7 effector." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 45, pp. 19338-43, (2010) (PubMed).

    Gao, Kang, Liao, Ding, Gambotto, Watkins, Liu, Stolz, Yin: "Biochemical isolation and characterization of the tubulovesicular LC3-positive autophagosomal compartment." dans: The Journal of biological chemistry, Vol. 285, Issue 2, pp. 1371-83, (2010) (PubMed).

    Sun, Fan, Chen, Ding, Chen, Zhong: "Identification of Barkor as a mammalian autophagy-specific factor for Beclin 1 and class III phosphatidylinositol 3-kinase." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 49, pp. 19211-6, (2008) (PubMed).

    Han, Hou, Goldstein, Lu, Stolz, Yin, Rabinowich: "Involvement of protective autophagy in TRAIL resistance of apoptosis-defective tumor cells." dans: The Journal of biological chemistry, Vol. 283, Issue 28, pp. 19665-77, (2008) (PubMed).

  • Antigène
    UVRAG (UV Radiation Resistance Associated Gene (UVRAG))
    Autre désignation
    UVRAG (UVRAG Produits)
    Synonymes
    anticorps DHTX, anticorps VPS38, anticorps p63, anticorps 9530039D02Rik, anticorps AI648770, anticorps BB124205, anticorps Uvrag1, anticorps Uvragl, anticorps zgc:56164, anticorps uvrag, anticorps MGC81810, anticorps UVRAG, anticorps MGC131135, anticorps CG6116, anticorps Dmel\\CG6116, anticorps UV radiation resistance associated, anticorps UV radiation resistance associated gene, anticorps UV radiation resistance associated S homeolog, anticorps UV radiation resistance associated L homeolog, anticorps UV-resistance associated gene, anticorps UVRAG, anticorps Uvrag, anticorps uvrag, anticorps uvrag.S, anticorps uvrag.L
    Sujet
    UVRAG complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells and encodes a protein with a C2 domain. The protein activates the Beclin1-PI(3)KC3 complex, promoting autophagy and suppressing the proliferation and tumorigenicity of human colon cancer cells. Chromosomal aberrations involving this gene are associated with left-right axis malformation and mutations in this gene have been associated with colon cancer.
    Poids moléculaire
    78151
    ID gène
    7405
    NCBI Accession
    NP_003360
    UniProt
    Q9P2Y5
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