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Osteocalcin anticorps (N-Term)

BGLAP Reactivité: Humain WB, IHC (p) Hôte: Lapin Polyclonal RB04507-04508 unconjugated
N° du produit ABIN388727
  • Antigène Voir toutes Osteocalcin (BGLAP) Anticorps
    Osteocalcin (BGLAP)
    Épitope
    • 15
    • 10
    • 9
    • 8
    • 7
    • 7
    • 7
    • 7
    • 6
    • 6
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 2-32, N-Term
    Reactivité
    • 100
    • 43
    • 21
    • 20
    • 19
    • 15
    • 15
    • 10
    • 8
    • 7
    • 4
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 91
    • 32
    • 2
    • 2
    • 1
    Lapin
    Clonalité
    • 95
    • 33
    Polyclonal
    Conjugué
    • 74
    • 13
    • 11
    • 8
    • 6
    • 5
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp Osteocalcin est non-conjugé
    Application
    • 96
    • 71
    • 50
    • 15
    • 15
    • 14
    • 14
    • 9
    • 9
    • 8
    • 8
    • 6
    • 5
    • 2
    • 2
    • 2
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Purification
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    Immunogène
    This Osteocalcin antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 2-32 amino acids from the N-terminal region of human Osteocalcin.
    Clone
    RB04507-04508
    Isotype
    Ig Fraction
    Top Product
    Discover our top product BGLAP Anticorps primaire
  • Indications d'application
    WB: 1:2000. IHC-P: 1:50~100
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Date de péremption
    6 months
  • Antigène
    Osteocalcin (BGLAP)
    Autre désignation
    Osteocalcin (BGLAP Produits)
    Synonymes
    anticorps BGP, anticorps OC, anticorps OCN, anticorps Bglap1, anticorps Bglap2, anticorps OG1, anticorps mOC-A, anticorps Bgp, anticorps Bgpr, anticorps Bgpra, anticorps bgp, anticorps LOC792433, anticorps ocn, anticorps GLA, anticorps BGLAP, anticorps PMF1, anticorps bone gamma-carboxyglutamate protein, anticorps bone gamma carboxyglutamate protein, anticorps bone gamma-carboxyglutamate protein S homeolog, anticorps bone gamma-carboxyglutamate (gla) protein, anticorps osteocalcin, anticorps polyamine-modulated factor 1, anticorps BGLAP, anticorps Bglap, anticorps bglap.S, anticorps bglap, anticorps ocn, anticorps LOC100529177, anticorps LOC100146589
    Sujet
    Prior to the formation of calcified bone, noncollagenous proteins form in the extracellular bone matrix. Gamma-carboxyglutamic acid residues are formed by vitamin K, vitamin-D regulated calcium binding proteins containing residues of Gla. These residues are essential for the binding of calcium and constitue 1-2 % of total bone protein. Osteocalcin itself binds strongly to apatite and calcium. Production of osteocalcin is expressed late in normal bone development and is characteristic of mature osteoblasts. Regular osteocalcin production has been shown to be linked to the p53 tumor suppressor gene. The p53 gene undergoes rearrangement in a high percentage of osteosarcomas, resulting in loss of its expression. The loss of p53 regulation inhibits further osteocalcin production. The absence of end-point differentiation in bone due to p53 rearrangements and lack of osteocalcin production may contribute to the maintenance of the tumorigenic phenotype in osteosarcomas.
    Poids moléculaire
    10963
    ID gène
    632
    NCBI Accession
    NP_954642
    UniProt
    P02818
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