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AKT1 anticorps (pSer129)
AKT1
Reactivité: Humain
DB
Hôte: Lapin
Polyclonal
RB25385
unconjugated
Détail du produit anti-AKT1 anticorps
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Antigène
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AKT1
(V-Akt Murine Thymoma Viral Oncogene Homolog 1 (AKT1))
Épitope
Tous les épitopes à travers AKT1 Anticorps.
pSer129
Reactivité
Toutes les réactivités sur AKT1 Anticorps
Humain
Hôte
Toutes les hôtes sur AKT1 Anticorps
Lapin
Clonalité
Toutes les clonalités sur AKT1 Anticorps
Polyclonal
Conjugué
Tous les conjugués à travers AKT1 Anticorps
Cet anticorp AKT1 est non-conjugé
Application
Tous les applications à travers AKT1 Anticorps.
Dot Blot (DB)
Homologie
M, Rat
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogène
This AKT1 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S129 of human AKT1.
Clone
RB25385
Isotype
Ig Fraction
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Alternatives
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Information d'application
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Indications d'application
DB: 1:500
Restrictions
For Research Use only
Stockage
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Format
Liquid
Buffer
Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Agent conservateur
Sodium azide
Précaution d'utilisation
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Stock
4 °C,-20 °C
Stockage commentaire
Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Date de péremption
6 months
Références pour anticorps anti-AKT1 (ABIN389509)
(cache)
Bestgen, Belaid-Choucair, Lomberget, Le Borgne, Filhol, Cochet : "In Search of Small Molecule Inhibitors Targeting the Flexible CK2 Subunit Interface. " dans: Pharmaceuticals (Basel, Switzerland) , Vol. 10 , Issue 1 , (2017 ) (PubMed ).
Melão, Spit, Cardoso, Barata : "Optimal interleukin-7 receptor-mediated signaling, cell cycle progression and viability of T-cell acute lymphoblastic leukemia cells rely on casein kinase 2 activity. " dans: Haematologica , Vol. 101 , Issue 11 , pp. 1368-1379 , (2016 ) (PubMed ).
Détails sur AKT1
(cache)
Antigène
AKT1
(V-Akt Murine Thymoma Viral Oncogene Homolog 1 (AKT1))
Autre désignation
AKT1 (AKT1 Produits )
Synonymes
anticorps AKT, anticorps CWS6, anticorps PKB, anticorps PKB-ALPHA, anticorps PRKBA, anticorps RAC, anticorps RAC-ALPHA, anticorps Akt, anticorps Rac, anticorps PKB/Akt, anticorps PKBalpha, anticorps AKT/PKB, anticorps AKT1, anticorps Akt/PKB, anticorps Akt1, anticorps CG4006, anticorps D-Akt, anticorps DAKT1, anticorps DAKT1/PKB, anticorps DAkt, anticorps DAkt1, anticorps DPKB, anticorps DRAC-PK, anticorps DRAC-PK66, anticorps DRAC-PK85, anticorps Dakt, anticorps Dakt1, anticorps Dmel\\CG4006, anticorps Dpkb, anticorps PKB/AKT, anticorps PKB/dAKT, anticorps RacPK, anticorps akt, anticorps akt1, anticorps dAKT, anticorps dAKT/dPKB, anticorps dAKT1, anticorps dAkt, anticorps dAkt/PKB, anticorps dAkt1, anticorps dPKB, anticorps dakt, anticorps dakt1, anticorps l(3)04226, anticorps l(3)89Bq, anticorps p-Akt, anticorps pAkt, anticorps ACT-5, anticorps akt-1, anticorps pkb, anticorps v-akt, anticorps v-akt1, anticorps xAct, anticorps ATAKT1, anticorps F18A8.2, anticorps F18A8_2, anticorps K+ transporter 1, anticorps POTASSIUM TRANSPORTER, anticorps AKT serine/threonine kinase 1, anticorps thymoma viral proto-oncogene 1, anticorps CG4006 gene product from transcript CG4006-RE, anticorps actin beta, anticorps v-akt murine thymoma viral oncogene homolog 1 S homeolog, anticorps v-akt murine thymoma viral oncogene homolog 1, anticorps K+ transporter 1, anticorps Serine/threonine-protein kinase akt-1, anticorps AKT1, anticorps Akt1, anticorps ACTB, anticorps akt1.S, anticorps akt1, anticorps KT1, anticorps akt-1
Sujet
The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery.
Poids moléculaire
55686
ID gène
207
NCBI Accession
NP_001014431 , NP_001014432 , NP_005154
UniProt
P31749
Pathways
Signalisation PI3K-Akt , Signalisation RTK , TCR Signaling , AMPK Signaling , Interferon-gamma Pathway , Signalisation TLR , Fc-epsilon Receptor Signaling Pathway , EGFR Signaling Pathway , Neurotrophin Signaling Pathway , Response to Water Deprivation , Regulation of Actin Filament Polymerization , Carbohydrate Homeostasis , Glycosaminoglycan Metabolic Process , Cellular Glucan Metabolic Process , Regulation of Muscle Cell Differentiation , Cell-Cell Junction Organization , Regulation of Cell Size , Skeletal Muscle Fiber Development , Regulation of Carbohydrate Metabolic Process , Hepatitis C , Protein targeting to Nucleus , CXCR4-mediated Signaling Events , Signaling Events mediated by VEGFR1 and VEGFR2 , Negative Regulation of intrinsic apoptotic Signaling , Thromboxane A2 Receptor Signaling , Signaling of Hepatocyte Growth Factor Receptor , Positive Regulation of fat Cell Differentiation , VEGFR1 Specific Signals , VEGF Signaling , L'effet Warburg
Vus récemment
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