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CDC25A anticorps (pThr507)

CDC25A Reactivité: Humain WB, IHC (p), IF Hôte: Lapin Polyclonal RB7856 unconjugated
N° du produit ABIN389532
  • Antigène Voir toutes CDC25A Anticorps
    CDC25A (Cell Division Cycle 25 Homolog A (S. Pombe) (CDC25A))
    Épitope
    • 34
    • 32
    • 21
    • 17
    • 15
    • 12
    • 9
    • 9
    • 8
    • 8
    • 7
    • 7
    • 7
    • 6
    • 6
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 480-514, pThr507
    Reactivité
    • 234
    • 93
    • 77
    • 5
    • 4
    • 4
    • 4
    • 4
    • 2
    Humain
    Hôte
    • 243
    • 7
    Lapin
    Clonalité
    • 244
    • 6
    Polyclonal
    Conjugué
    • 107
    • 21
    • 16
    • 15
    • 11
    • 11
    • 9
    • 9
    • 9
    • 9
    • 9
    • 9
    • 3
    • 3
    • 3
    • 3
    • 3
    Cet anticorp CDC25A est non-conjugé
    Application
    • 192
    • 124
    • 69
    • 40
    • 40
    • 31
    • 20
    • 17
    • 15
    • 8
    • 7
    • 6
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)
    Homologie
    B, M, Rat
    Purification
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogène
    This CDC25A Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding T507 of human CDC25A.
    Clone
    RB7856
    Isotype
    Ig Fraction
    Top Product
    Discover our top product CDC25A Anticorps primaire
  • Indications d'application
    IF: 1:25. WB: 1:250. WB: 1:1000. IHC-P: 1:50~100
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C.
    Date de péremption
    6 months
  • Chou, Yen, Lee, Chen: "Pro-apoptotic role of Cdc25A: activation of cyclin B1/Cdc2 by the Cdc25A C-terminal domain." dans: The Journal of biological chemistry, Vol. 285, Issue 23, pp. 17833-45, (2010) (PubMed).

    Kasahara, Goto, Enomoto, Tomono, Kiyono, Inagaki: "14-3-3gamma mediates Cdc25A proteolysis to block premature mitotic entry after DNA damage." dans: The EMBO journal, Vol. 29, Issue 16, pp. 2802-12, (2010) (PubMed).

  • Antigène
    CDC25A (Cell Division Cycle 25 Homolog A (S. Pombe) (CDC25A))
    Autre désignation
    CDC25A (CDC25A Produits)
    Synonymes
    anticorps cdc25a2, anticorps cdc25A, anticorps sb:cb317, anticorps CDC25A2, anticorps D9Ertd393e, anticorps cell division cycle 25A, anticorps cell division cycle 25B, anticorps cell division cycle 25A S homeolog, anticorps CDC25A, anticorps cdc25a, anticorps cdc25b, anticorps Cdc25a, anticorps cdc25a.S
    Sujet
    CDC25A is a member of the CDC25 family of phosphatases. CDC25A is required for progression from G1 to the S phase of the cell cycle. It activates the cyclin-dependent kinase CDC2 by removing two phosphate groups. CDC25A is specifically degraded in response to DNA damage, which prevents cells with chromosomal abnormalities from progressing through cell division. CDC25A is an oncogene, although its exact role in oncogenesis has not been demonstrated. Two transcript variants encoding different isoforms have been found for this gene.
    Poids moléculaire
    59087
    NCBI Accession
    NP_001780, NP_963861
    UniProt
    P30304
    Pathways
    Cycle Cellulaire, Mitotic G1-G1/S Phases, M Phase
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