ABCB11 anticorps (C-Term)

N° du produit ABIN390059

Détail du produit anti-ABCB11 anticorps

Antigène: ABCB11 (ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 11 (ABCB11))

Épitope: AA 1038-1067, C-Term

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ABCB11 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogène: This ABCB11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1038-1067 amino acids from the C-terminal region of human ABCB11.

Clone: RB2211

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000. IHC-P: 1:50~100

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid freeze-thaw cycles.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots.

Date de péremption: 6 months

Références pour anticorps anti-ABCB11 (ABIN390059)

Bochkis, Rubins, White, Furth, Friedman, Kaestner: "Hepatocyte-specific ablation of Foxa2 alters bile acid homeostasis and results in endoplasmic reticulum stress." dans: Nature medicine, Vol. 14, Issue 8, pp. 828-36, (2008) (PubMed).

Truog: ""Do-not-resuscitate" orders during anesthesia and surgery." dans: Anesthesiology, Vol. 74, Issue 3, pp. 606-8, (1991) (PubMed).

Détails sur ABCB11

Antigène: ABCB11 (ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 11 (ABCB11))

Autre désignation: ABCB11 (ABCB11 Produits)

Synonymes: anticorps ABCB11, anticorps Bsep, anticorps ABC16, anticorps BRIC2, anticorps BSEP, anticorps PFIC-2, anticorps PFIC2, anticorps PGY4, anticorps SPGP, anticorps Lith1, anticorps BSEP/SPGP, anticorps Spgp, anticorps ATP binding cassette subfamily B member 11, anticorps bile salt export pump, anticorps ATP-binding cassette, sub-family B (MDR/TAP), member 11, anticorps ABCB11, anticorps LOC100489744, anticorps LOC100565276, anticorps EDI_111220, anticorps EDI_272930, anticorps abcb11, anticorps Abcb11

Sujet: ABCB11 is involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes. It is expressed predominatly, if not exclusively, in the liver, where it is further localized to the canilicular microvilli and to subcanilicular vesicles fo the hepatocytes. Structurally, ABCB11 is a multifunctional polypeptide with two homologus halves, each containing a hydrophobic membrane-anchoring domain and an ATP binding cassette (ABC) domain. Defects in ABCB11 are the cause of progressive familial intrahepatic cholestasis 2 (PFIC2). PFIC2 is an inherited liver disease of childhood which is characterized by cholestasis and normal serum gamma-glutamyltransferase activity. Defects in ABCB11 are also found in cases of chronic intrahepatic cholestasis without obvious familial history of chronic liver disease.

Poids moléculaire: 146407

ID gène: 8647

NCBI Accession: NP_003733

UniProt: O95342