LRP6 anticorps (C-Term)

N° du produit ABIN390100

Détail du produit anti-LRP6 anticorps

Antigène: LRP6 (Low Density Lipoprotein Receptor-Related Protein 6 (LRP6))

Épitope: AA 1531-1560, C-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp LRP6 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogène: This LRP6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1531-1560 amino acids from the C-terminal region of human LRP6.

Clone: RB01837

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000. IHC-P: 1:10~50

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 6 months

Références pour anticorps anti-LRP6 (ABIN390100)

Ye, Go, Singh, Liu, Keramati, Mani: "LRP6 protein regulates low density lipoprotein (LDL) receptor-mediated LDL uptake." dans: The Journal of biological chemistry, Vol. 287, Issue 2, pp. 1335-44, (2012) (PubMed).

Keramati, Singh, Lin, Faramarzi, Ye, Mane, Tellides, Lifton, Mani: "Wild-type LRP6 inhibits, whereas atherosclerosis-linked LRP6R611C increases PDGF-dependent vascular smooth muscle cell proliferation." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 108, Issue 5, pp. 1914-8, (2011) (PubMed).

Liu, Prior, Piwnica-Worms, Bu: "LRP6 overexpression defines a class of breast cancer subtype and is a target for therapy." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 11, pp. 5136-41, (2010) (PubMed).

Détails sur LRP6

Antigène: LRP6 (Low Density Lipoprotein Receptor-Related Protein 6 (LRP6))

Autre désignation: LRP6 (LRP6 Produits)

Synonymes: anticorps lrp6-A, anticorps Xlrp6, anticorps adcad2, anticorps lrp6, anticorps LRP6, anticorps ADCAD2, anticorps C030016K15Rik, anticorps Cd, anticorps Gw, anticorps LDL receptor related protein 6, anticorps LDL receptor related protein 6 L homeolog, anticorps LDL receptor related protein 6 S homeolog, anticorps low density lipoprotein receptor-related protein 6, anticorps low-density lipoprotein receptor-related protein 6, anticorps LRP6, anticorps lrp6.L, anticorps lrp6.S, anticorps lrp6, anticorps Lrp6, anticorps LOC590395

Sujet: LRP6 is essential for the Wnt/beta catenin signaling pathway, probably by acting as a coreceptor together with Frizzled for Wnt. It is a specific, high-affinity receptor for DKK1 and DKK2, but not DKK3. The interaction with DKK1 blocks LRP6-mediated Wnt/beta catenin signaling via LRP6 removal via Kremen proteins-mediated endocytosis.

Poids moléculaire: 180429

ID gène: 4040

NCBI Accession: NP_002327

UniProt: O75581

Pathways: Signalisation WNT, Tube Formation