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NR4A2 anticorps (N-Term)

NR4A2 Reactivité: Souris WB, IF, IHC (p) Hôte: Lapin Polyclonal RB7385 unconjugated
N° du produit ABIN390383
  • Antigène Voir toutes NR4A2 Anticorps
    NR4A2 (Nuclear Receptor Subfamily 4, Group A, Member 2 (NR4A2))
    Épitope
    • 15
    • 15
    • 6
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 13-42, N-Term
    Reactivité
    • 61
    • 45
    • 41
    • 5
    • 5
    • 4
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Souris
    Hôte
    • 61
    • 3
    Lapin
    Clonalité
    • 61
    • 3
    Polyclonal
    Conjugué
    • 34
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Cet anticorp NR4A2 est non-conjugé
    Application
    • 61
    • 26
    • 26
    • 17
    • 14
    • 11
    • 8
    • 7
    • 5
    • 4
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Homologie
    B, Rat
    Purification
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    Immunogène
    This NURR1 (NR4A2) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 13-42 amino acids from the N-terminal region of human NURR1 (NR4A2).
    Clone
    RB7385
    Isotype
    Ig Fraction
    Top Product
    Discover our top product NR4A2 Anticorps primaire
  • Indications d'application
    IF: 1:10~50. WB: 1:1000. IHC-P: 1:50~100
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Date de péremption
    6 months
  • Song, Zukor, Lin, Hascalovici, Liberman, Tavitian, Mui, Vali, Tong, Bhardwaj, Srivastava, Hamel, Schipper: "Schizophrenia-like features in transgenic mice overexpressing human HO-1 in the astrocytic compartment." dans: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 32, Issue 32, pp. 10841-53, (2012) (PubMed).

  • Antigène
    NR4A2 (Nuclear Receptor Subfamily 4, Group A, Member 2 (NR4A2))
    Autre désignation
    NURR1 (NR4A2) (NR4A2 Produits)
    Synonymes
    anticorps nr41/42/43, anticorps Nr4a2, anticorps nurr1, anticorps not, anticorps rnr1, anticorps hzf-3, anticorps tinur, anticorps NGFI-B, anticorps HZF-3, anticorps NOT, anticorps NURR1, anticorps RNR1, anticorps TINUR, anticorps Nurr1, anticorps RNR-1, anticorps TINOR, anticorps ngf1b, anticorps nr4a2, anticorps zgc:92696, anticorps nuclear receptor subfamily 4 group A member 2, anticorps nuclear receptor, anticorps nuclear receptor subfamily 4, group A, member 2, anticorps nuclear receptor subfamily 4, group A, member 2b, anticorps NR4A2, anticorps nr41/42/43, anticorps nr4a2, anticorps Nr4a2, anticorps nr4a2b
    Sujet
    Parkinson's disease (PD) is a multifactorial disease that appears to arise from the effects of both genetic and environmental influences. The known genetic factors include multiple genes that have been identified in related parkinsonian syndromes, as well as alpha-synuclein. Genes associated with either PD or Parkinson-related disorders include parkin, DJ-1, ubiquitin C-terminal hydrolase isozyme L1 (UCH-L1), nuclear receptor-related factor 1 (NURR1), and alpha-synuclein. Nurr1 is a transcription factor that is expressed in the embryonic ventral midbrain and is critical for the development of dopamine (DA) neurons. It belongs to the conserved family of nuclear receptors but lacks an identified ligand and is therefore referred to as an orphan receptor. RXR ligands can promote the survival of DA neurons via a process that depends on Nurr1-RXR heterodimers. In developing DA cells, Nurr1 is required for the expression of several genes important for DA synthesis and function. Nurr1 is also important for the maintenance of adult DA neurons.
    Poids moléculaire
    66591
    ID gène
    4929
    NCBI Accession
    NP_006177
    UniProt
    P43354
    Pathways
    Nuclear Receptor Transcription Pathway, Dopaminergic Neurogenesis, Steroid Hormone Mediated Signaling Pathway
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