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Caspase 8 anticorps (C-Term)

CASP8 Reactivité: Humain, Souris WB, FACS Hôte: Lapin Polyclonal RB18993 unconjugated
N° du produit ABIN390474
  • Antigène Voir toutes Caspase 8 (CASP8) Anticorps
    Caspase 8 (CASP8)
    Épitope
    • 16
    • 16
    • 9
    • 7
    • 6
    • 6
    • 5
    • 5
    • 5
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 432-461, C-Term
    Reactivité
    • 138
    • 69
    • 63
    • 23
    • 16
    • 16
    • 10
    • 1
    • 1
    • 1
    Humain, Souris
    Hôte
    • 129
    • 26
    • 6
    • 2
    Lapin
    Clonalité
    • 126
    • 36
    Polyclonal
    Conjugué
    • 98
    • 16
    • 11
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Cet anticorp Caspase 8 est non-conjugé
    Application
    • 143
    • 50
    • 44
    • 38
    • 27
    • 26
    • 25
    • 21
    • 20
    • 18
    • 8
    • 4
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Flow Cytometry (FACS)
    Purification
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogène
    This CASP8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 432-461 amino acids from the C-terminal region of human CASP8.
    Clone
    RB18993
    Isotype
    Ig Fraction
    Top Product
    Discover our top product CASP8 Anticorps primaire
  • Indications d'application
    WB: 1:2000. FC: 1:25
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Date de péremption
    6 months
  • Lin, Huang, Lin, Lin: "p-Cresol mediates autophagic cell death in renal proximal tubular cells." dans: Toxicology letters, Vol. 234, Issue 1, pp. 20-9, (2015) (PubMed).

  • Antigène
    Caspase 8 (CASP8)
    Autre désignation
    CASP8 (CASP8 Produits)
    Synonymes
    anticorps casp8-A, anticorps xCaspase-8, anticorps casp8, anticorps CASP8, anticorps CASP-8, anticorps FLICE, anticorps MACH, anticorps Mch5, anticorps ALPS2B, anticorps CAP4, anticorps Casp-8, anticorps MCH5, anticorps caspase-8, anticorps zgc:92075, anticorps caspase 8 L homeolog, anticorps death related ced-3/Nedd2-like protein, anticorps caspase 8, anticorps caspase-8, anticorps caspase-8-like, anticorps caspase 8, apoptosis-related cysteine peptidase, anticorps casp8.L, anticorps LOC661095, anticorps CASP8, anticorps LOC5563818, anticorps casp8, anticorps LOC100222284, anticorps Casp8
    Sujet
    CASP8 is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases.
    Poids moléculaire
    55391
    ID gène
    841
    NCBI Accession
    NP_001073593, NP_001073594, NP_001219, NP_203519, NP_203520, NP_203522
    UniProt
    Q14790
    Pathways
    Apoptose, Caspase Cascade in Apoptosis, Signalisation TLR, Activation of Innate immune Response, Tube Formation, Positive Regulation of Endopeptidase Activity, Toll-Like Receptors Cascades
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