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LATS1 anticorps (N-Term)

LATS1 Reactivité: Humain, Souris, Rat WB, IHC (p) Hôte: Lapin Polyclonal RB3029 unconjugated
N° du produit ABIN391033
  • Antigène Voir toutes LATS1 Anticorps
    LATS1 (LATS, Large Tumor Suppressor, Homolog 1 (Drosophila) (LATS1))
    Épitope
    • 16
    • 13
    • 8
    • 7
    • 7
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-30, N-Term
    Reactivité
    • 61
    • 47
    • 13
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Humain, Souris, Rat
    Hôte
    • 59
    • 2
    Lapin
    Clonalité
    • 60
    • 1
    Polyclonal
    Conjugué
    • 19
    • 6
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp LATS1 est non-conjugé
    Application
    • 41
    • 24
    • 16
    • 13
    • 13
    • 6
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Purification
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    Immunogène
    This LATS1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human LATS1.
    Clone
    RB3029
    Isotype
    Ig Fraction
    Top Product
    Discover our top product LATS1 Anticorps primaire
  • Indications d'application
    WB: 1:1000. IHC-P: 1:50~100
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Date de péremption
    6 months
  • Eiring, Neviani, Santhanam, Oaks, Chang, Notari, Willis, Gambacorti-Passerini, Volinia, Marcucci, Caligiuri, Leone, Perrotti: "Identification of novel posttranscriptional targets of the BCR/ABL oncoprotein by ribonomics: requirement of E2F3 for BCR/ABL leukemogenesis." dans: Blood, Vol. 111, Issue 2, pp. 816-28, (2008) (PubMed).

  • Antigène
    LATS1 (LATS, Large Tumor Suppressor, Homolog 1 (Drosophila) (LATS1))
    Autre désignation
    LATS1 (LATS1 Produits)
    Synonymes
    anticorps WARTS, anticorps wts, anticorps AW208599, anticorps Lats, anticorps si:dkey-181i3.5, anticorps wu:fc19a11, anticorps zgc:123219, anticorps lats1, anticorps RGD1564085, anticorps warts, anticorps large tumor suppressor kinase 1, anticorps large tumor suppressor, anticorps large tumor suppressor kinase 1 S homeolog, anticorps LATS1, anticorps Lats1, anticorps lats1, anticorps lats1.S
    Sujet
    The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments.
    Poids moléculaire
    126870
    ID gène
    9113
    NCBI Accession
    NP_001257448, NP_004681
    UniProt
    O95835
    Pathways
    Regulation of Actin Filament Polymerization, Maintenance of Protein Location
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