DCK anticorps (C-Term)

N° du produit ABIN391125

Détail du produit anti-DCK anticorps

Antigène: DCK (Deoxycytidine Kinase (DCK))

Épitope: AA 171-200, C-Term

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DCK est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogène: This DCK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 171-200 amino acids from the C-terminal region of human DCK.

Clone: RB05276

Isotype: Ig Fraction

Information d'application

Indications d'application: IF: 1:10~50. IP: 1:500~1000. WB: 1:1000. IHC-P: 1:10~50

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 6 months

Références pour anticorps anti-DCK (ABIN391125)

Hartford, Duan, Delaney, Mi, Kistner, Lamba, Huang, Dolan: "Population-specific genetic variants important in susceptibility to cytarabine arabinoside cytotoxicity." dans: Blood, Vol. 113, Issue 10, pp. 2145-53, (2009) (PubMed).

Lamba, Crews, Pounds, Schuetz, Gresham, Gandhi, Plunkett, Rubnitz, Ribeiro: "Pharmacogenetics of deoxycytidine kinase: identification and characterization of novel genetic variants." dans: The Journal of pharmacology and experimental therapeutics, Vol. 323, Issue 3, pp. 935-45, (2007) (PubMed).

Détails sur DCK

Antigène: DCK (Deoxycytidine Kinase (DCK))

Autre désignation: DCK (DCK Produits)

Synonymes: anticorps dck, anticorps DCK, anticorps wu:fc15f06, anticorps zgc:101771, anticorps dck1, anticorps deoxycytidine kinase, anticorps deoxycytidine kinase, gene 2 L homeolog, anticorps deoxycytidine kinase, gene 2, anticorps Deoxycytidine kinase, anticorps deoxycytidine kinase, gene 1 L homeolog, anticorps DCK, anticorps dck, anticorps dck.2.L, anticorps dck.2, anticorps Dck, anticorps FPV059, anticorps FPV151, anticorps dck.1.L

Sujet: Deoxycytidine kinase is responsible for the phosphorylation of several deoxyribonucleosides and their analogs. Deficiency of this enzyme activity is associated with resistance to antiviral and anticancer chemotherapeutic agents, whereas increased enzyme activity is associated with increased activation of these compounds to cytotoxic nucleoside triphosphate derivatives. It is the rate limiting enzyme in the activation of many important anticancer and retroviral drugs and its activity is often decreased in cells that are resistant to cytosine arabinoside.

Poids moléculaire: 30519

ID gène: 1633

NCBI Accession: NP_000779

UniProt: P27707