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ACVR2B anticorps (AA 1-30)

ACVR2B Reactivité: Humain WB Hôte: Lapin Polyclonal RB08166 unconjugated
N° du produit ABIN391162
  • Antigène Voir toutes ACVR2B Anticorps
    ACVR2B (Activin A Receptor, Type IIB (ACVR2B))
    Épitope
    • 15
    • 9
    • 8
    • 7
    • 7
    • 7
    • 7
    • 6
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-30
    Reactivité
    • 76
    • 31
    • 31
    • 11
    • 10
    • 7
    • 6
    • 6
    • 6
    • 5
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    Humain
    Hôte
    • 74
    • 7
    • 3
    Lapin
    Clonalité
    • 79
    • 5
    Polyclonal
    Conjugué
    • 37
    • 13
    • 5
    • 5
    • 5
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp ACVR2B est non-conjugé
    Application
    • 79
    • 28
    • 27
    • 13
    • 13
    • 8
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Purification
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    Immunogène
    This ACVR2B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected between aa 1 and 30 of human ACVR2B.
    Clone
    RB08166
    Isotype
    Ig Fraction
    Top Product
    Discover our top product ACVR2B Anticorps primaire
  • Indications d'application
    WB: 1:1000. WB: 1:1000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Date de péremption
    6 months
  • McKay, Ogborn, Bellamy, Tarnopolsky, Parise: "Myostatin is associated with age-related human muscle stem cell dysfunction." dans: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 26, Issue 6, pp. 2509-21, (2012) (PubMed).

  • Antigène
    ACVR2B (Activin A Receptor, Type IIB (ACVR2B))
    Autre désignation
    ACVR2B (ACVR2B Produits)
    Synonymes
    anticorps ACVR2B, anticorps XAR1, anticorps actr-iib, anticorps actriib, anticorps ACTRIIB, anticorps ActR-IIB, anticorps HTX4, anticorps ActRIIB, anticorps actr2b, anticorps actrIIb, anticorps wu:fj97d11, anticorps activin A receptor type 2B, anticorps activin A receptor type 2B L homeolog, anticorps activin A receptor type 2Ba, anticorps activin receptor IIB, anticorps ACVR2B, anticorps acvr2b, anticorps acvr2b.L, anticorps Acvr2b, anticorps acvr2ba
    Sujet
    Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling, and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. ACVR2B (activin A type IIB receptor) displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor.
    Poids moléculaire
    57724
    ID gène
    93
    NCBI Accession
    NP_001097
    UniProt
    Q13705
    Pathways
    Hormone Transport, Cancer Immune Checkpoints
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