SPHK2 anticorps (N-Term)

N° du produit ABIN391348

Détail du produit anti-SPHK2 anticorps

Antigène: SPHK2 (Sphingosine Kinase 2 (SPHK2))

Épitope: AA 1-30, N-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SPHK2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogène: This SPHK2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human SPHK2.

Clone: RB03623

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000. IHC-P: 1:50~100

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C.

Date de péremption: 6 months

Références pour anticorps anti-SPHK2 (ABIN391348)

Song, Zhang, Chen, Xia, Qin, Waeber, Sheng: "Sphingosine kinase 2 activates autophagy and protects neurons against ischemic injury through interaction with Bcl-2 via its putative BH3 domain." dans: Cell death & disease, Vol. 8, Issue 7, pp. e2912, (2018) (PubMed).

Gairhe, Joshi, Bastola, McLendon, Oka, Fagan, McMurtry: "Sphingosine-1-phosphate is involved in the occlusive arteriopathy of pulmonary arterial hypertension." dans: Pulmonary circulation, Vol. 6, Issue 3, pp. 369-80, (2016) (PubMed).

Sun, Zhang, Wang, Wang, Ma, Lei, Zhou, Sun, Lu, Liu, Han: "Down-regulation of Sphk2 suppresses bladder cancer progression." dans: Tumour biology, (2015) (PubMed).

Sheng, Zhang, Felice, Qin, Qin, Smith, Sapp, Difiglia, Waeber: "Preconditioning stimuli induce autophagy via sphingosine kinase 2 in mouse cortical neurons." dans: The Journal of biological chemistry, Vol. 289, Issue 30, pp. 20845-57, (2014) (PubMed).

Candela, Geraci, Turturici, Taverna, Albanese, Sconzo: "Membrane vesicles containing matrix metalloproteinase-9 and fibroblast growth factor-2 are released into the extracellular space from mouse mesoangioblast stem cells." dans: Journal of cellular physiology, Vol. 224, Issue 1, pp. 144-51, (2010) (PubMed).

Weigert, Cremer, Schmidt, von Knethen, Angioni, Geisslinger, Brüne: "Cleavage of sphingosine kinase 2 by caspase-1 provokes its release from apoptotic cells." dans: Blood, Vol. 115, Issue 17, pp. 3531-40, (2010) (PubMed).

Wadgaonkar, Patel, Grinkina, Romano, Liu, Zhao, Sammani, Garcia, Natarajan: "Differential regulation of sphingosine kinases 1 and 2 in lung injury." dans: American journal of physiology. Lung cellular and molecular physiology, Vol. 296, Issue 4, pp. L603-13, (2009) (PubMed).

Coste, Brenneis, Linke, Pierre, Maeurer, Becker, Schmidt, Gao, Geisslinger, Scholich: "Sphingosine 1-phosphate modulates spinal nociceptive processing." dans: The Journal of biological chemistry, Vol. 283, Issue 47, pp. 32442-51, (2008) (PubMed).

Détails sur SPHK2

Antigène: SPHK2 (Sphingosine Kinase 2 (SPHK2))

Autre désignation: SPHK2 (SPHK2 Produits)

Sujet: Sphingosine Kinase (SphK) catalyzes the phosphorylation of the lipid sphingosine, creating the bioactive lipid sphingosine-1-phosphate (S1P). S1P subsequently signals through cell surface G protein-coupled receptors, as well as intracellularly, to modulate cell proliferation, survival, motility and differentiation. SphK is an important signaling enzyme which is activated by diverse agents, including growth factors that signal through receptor tyrosine kinases, agents activating G protein-coupled receptors, and immunoglobulin receptors. Two SphK isotypes, SphK-1 and SphK-2, have been cloned, and both isotypes are ubiquitously expressed. SphK-1 has been shown to mediate cell growth, prevention of apoptosis, and cellular transformation, and is upregulated in a variety of human tumors. In contrast, SphK-2 increases apoptosis, and may be responsible for phosphorylating and activating the immunosuppressive drug FTY720.

Poids moléculaire: 69217

NCBI Accession: NP_001191087, NP_001191088, NP_001191089, NP_064511

UniProt: Q9NRA0

Pathways: VEGF Signaling