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ROR2 anticorps (N-Term)

ROR2 Reactivité: Humain WB, FACS, IHC (p) Hôte: Lapin Polyclonal RB01507-01508 unconjugated
N° du produit ABIN392044
  • Antigène Voir toutes ROR2 Anticorps
    ROR2 (Receptor Tyrosine Kinase-Like Orphan Receptor 2 (ROR2))
    Épitope
    • 12
    • 9
    • 7
    • 7
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 19-50, N-Term
    Reactivité
    • 74
    • 27
    • 25
    • 1
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 68
    • 9
    Lapin
    Clonalité
    • 66
    • 11
    Polyclonal
    Conjugué
    • 37
    • 6
    • 6
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp ROR2 est non-conjugé
    Application
    • 51
    • 35
    • 30
    • 15
    • 7
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Purification
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    Immunogène
    This ROR2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 19-50 amino acids from the N-terminal region of human ROR2.
    Clone
    RB01507-01508
    Isotype
    Ig Fraction
    Top Product
    Discover our top product ROR2 Anticorps primaire
  • Indications d'application
    WB: 1:1000. IHC-P: 1:10~50. FC: 1:10~50
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Date de péremption
    6 months
  • Wu, Xiong, Wang, Miao, Liu, Li, Zou, Liu, Zhao, Yang: "Comparative study of ROR2 and WNT5a expression in squamous/adenosquamous carcinoma and adenocarcinoma of the gallbladder." dans: World journal of gastroenterology, Vol. 23, Issue 14, pp. 2601-2612, (2018) (PubMed).

    Ma, Henry, Llamosas, Higgins, Daniels, Hesson, Hawkins, Ward, Ford: "Validation of specificity of antibodies for immunohistochemistry: the case of ROR2." dans: Virchows Archiv : an international journal of pathology, (2016) (PubMed).

    OConnell, Fiori, Xu, Carter, Frank, Camilli, French, Dissanayake, Indig, Bernier, Taub, Hewitt, Weeraratna: "The orphan tyrosine kinase receptor, ROR2, mediates Wnt5A signaling in metastatic melanoma." dans: Oncogene, Vol. 29, Issue 1, pp. 34-44, (2010) (PubMed).

  • Antigène
    ROR2 (Receptor Tyrosine Kinase-Like Orphan Receptor 2 (ROR2))
    Autre désignation
    ROR2 (ROR2 Produits)
    Synonymes
    anticorps BDB, anticorps BDB1, anticorps NTRKR2, anticorps Ntrkr2, anticorps mRor2, anticorps ROR2, anticorps bdb, anticorps bdb1, anticorps Xror2, anticorps ntrkr2, anticorps MGC97773, anticorps LOC100219935, anticorps ror2, anticorps xror2, anticorps receptor tyrosine kinase like orphan receptor 2, anticorps receptor tyrosine kinase-like orphan receptor 2, anticorps receptor tyrosine kinase like orphan receptor 2 L homeolog, anticorps ROR2, anticorps Ror2, anticorps ror2, anticorps ror2.L
    Sujet
    ROR2 is a tyrosine-protein kinase receptor which may be involved in the early formation of the chondrocytes. It seems to be required for cartilage and growth plate development. This Type I membrane protein is expressed at high levels during early embryonic development. The expression levels drop strongly around day 16 and there are only very low levels in adult tissues. Defects in ROR2 are a cause of brachydactyly type B1 (BDB1). BDB1 is an autosomal dominant skeletal disorder characterized by hypoplasia/aplasia of distal phalanges and nails. In BDB1 the middle phalanges are short but in addition the terminal phalanges are rudimentary or absent. Both fingers and toes are affected. The thumbs and big toes are usually deformed. Defects in ROR2 are a cause of recessive Robinow syndrome (RRS). RRS is an autosomal disorder characterized by skeletal dysplasia with generalized limb bone shortening, segmental defects of the spine, brachydactyly and a dysmorphic facial appearance. The protein contains 1 frizzled (FZ) domain, 1 immunoglobulin-like C2-type domain, and 1 kringle domain.
    Poids moléculaire
    104757
    ID gène
    4920
    NCBI Accession
    NP_004551
    UniProt
    Q01974
    Pathways
    Signalisation RTK, Signalisation WNT
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