Tel:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@anticorps-enligne.fr

BACE1 anticorps (N-Term)

BACE1 Reactivité: Humain, Souris WB, IHC (p) Hôte: Lapin Polyclonal RB16874 unconjugated
N° du produit ABIN392201
  • Antigène Voir toutes BACE1 Anticorps
    BACE1 (Beta-secretase 1 (BACE1))
    Épitope
    • 16
    • 13
    • 5
    • 5
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 38-70, N-Term
    Reactivité
    • 82
    • 51
    • 41
    • 7
    • 6
    • 5
    • 5
    • 5
    • 5
    • 5
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    Humain, Souris
    Hôte
    • 76
    • 11
    Lapin
    Clonalité
    • 71
    • 16
    Polyclonal
    Conjugué
    • 56
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp BACE1 est non-conjugé
    Application
    • 64
    • 37
    • 29
    • 18
    • 13
    • 13
    • 13
    • 11
    • 11
    • 7
    • 3
    • 3
    • 3
    • 2
    • 2
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Homologie
    B, Rat
    Purification
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    Immunogène
    This BACE1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 38-70 amino acids from the N-terminal region of human BACE1.
    Clone
    RB16874
    Isotype
    Ig Fraction
    Top Product
    Discover our top product BACE1 Anticorps primaire
  • Indications d'application
    WB: 1:1000. WB: 1:1000. IHC-P: 1:10~50
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Date de péremption
    6 months
  • Lu, Cui, Li, Wang, Zhou, Yang, Chen, Zhao, Pei: "An Anti-Parkinson's Disease Drug via Targeting Adenosine A2A Receptor Enhances Amyloid-β Generation and γ-Secretase Activity." dans: PLoS ONE, Vol. 11, Issue 11, pp. e0166415, (2017) (PubMed).

    Lu, Li, Wang, Pei: "Dopamine D2 receptor and β-arrestin 2 mediate Amyloid-β elevation induced by anti-parkinson's disease drugs, levodopa and piribedil, in neuronal cells." dans: PLoS ONE, Vol. 12, Issue 3, pp. e0173240, (2017) (PubMed).

    Li, Cui, Yu, Li, Hou, Wang, Qin, Zhao, Yao, Zhao, Pei: "Traditional Chinese Nootropic Medicine Radix Polygalae and Its Active Constituent Onjisaponin B Reduce β-Amyloid Production and Improve Cognitive Impairments." dans: PLoS ONE, Vol. 11, Issue 3, pp. e0151147, (2016) (PubMed).

    Nie, Li, Yan, Wang, Zhao, Guo, Yin: "Nicotine decreases beta-amyloid through regulating BACE1 transcription in SH-EP1-?4?2 nAChR-APP695 cells." dans: Neurochemical research, Vol. 36, Issue 5, pp. 904-12, (2011) (PubMed).

  • Antigène
    BACE1 (Beta-secretase 1 (BACE1))
    Autre désignation
    BACE1 (BACE1 Produits)
    Synonymes
    anticorps ASP2, anticorps BACE, anticorps HSPC104, anticorps C76936, anticorps Bace, anticorps MGC145931, anticorps BACE1, anticorps zgc:77409, anticorps beta-secretase 1, anticorps beta-site APP cleaving enzyme 1, anticorps beta-site APP-cleaving enzyme 1, anticorps BACE1, anticorps Bace1, anticorps bace1
    Sujet
    Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein (APP) by two proteases, one of which is BACE. This protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi.
    Poids moléculaire
    55764
    ID gène
    23621
    NCBI Accession
    NP_001193978, NP_036236, NP_620427, NP_620428, NP_620429
    UniProt
    P56817
Vous êtes ici:
Support technique