ACVR1 anticorps (AA 132-162)

N° du produit ABIN392240

Détail du produit anti-ACVR1 anticorps

Antigène: ACVR1 (ACRV1) (Activin Receptor Type I (ACRV1))

Épitope: AA 132-162

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ACVR1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Homologie: B, M, Rat

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogène: This Activin Receptor Type IA (ACVR1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 132-162 amino acids from the Central region of human Activin Receptor Type IA (ACVR1).

Clone: RB03507-03508

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000. WB: 1:1000. WB: 1:1000. IHC-P: 1:50~100

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 6 months

Références pour anticorps anti-ACVR1 (ABIN392240)

Mitu, Wang, Hirschberg: "BMP7 is a podocyte survival factor and rescues podocytes from diabetic injury." dans: American journal of physiology. Renal physiology, Vol. 293, Issue 5, pp. F1641-8, (2007) (PubMed).

Weber, Teresi, Broelsch, Frilling, Eng: "A limited set of human MicroRNA is deregulated in follicular thyroid carcinoma." dans: The Journal of clinical endocrinology and metabolism, Vol. 91, Issue 9, pp. 3584-91, (2006) (PubMed).

Détails sur ACVR1

Antigène: ACVR1 (ACRV1) (Activin Receptor Type I (ACRV1))

Autre désignation: Activin Receptor Type IA (ACVR1) (ACRV1 Produits)

Synonymes: anticorps ACTRI, anticorps ACVR1A, anticorps ACVRLK2, anticorps ALK2, anticorps FOP, anticorps SKR1, anticorps TSRI, anticorps ActR-IA, anticorps ActR-I, anticorps ActRIA, anticorps Acvr, anticorps Acvrlk2, anticorps Alk-2, anticorps Alk8, anticorps D330013D15Rik, anticorps Tsk7L, anticorps actri, anticorps acvr1, anticorps acvr1-a, anticorps acvr1-b, anticorps acvr1a, anticorps acvrlk2, anticorps alk-2, anticorps alk2, anticorps alk8, anticorps fop, anticorps sax, anticorps skr1, anticorps tsri, anticorps xALK-2, anticorps activin A receptor type 1, anticorps activin A receptor, type 1, anticorps activin A receptor type 1 S homeolog, anticorps ACVR1, anticorps Acvr1, anticorps acvr1.S

Sujet: Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling, and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. ACVR1 (activin A type I receptor) signals a particular transcriptional response in concert with activin type II receptors.

Poids moléculaire: 57153

ID gène: 90

NCBI Accession: NP_001096, NP_001104537

UniProt: Q04771