This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Immunogène
This ACVRL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 474-503 amino acids from the C-terminal region of human ACVRL1.
anticorps ACVRL1, anticorps vgb, anticorps alk1, anticorps zehn1109, anticorps hm:zehn1109, anticorps ACVRLK1, anticorps ALK-1, anticorps ALK1, anticorps HHT, anticorps HHT2, anticorps ORW2, anticorps SKR3, anticorps TSR-I, anticorps R-3, anticorps R3, anticorps SETHKIR, anticorps AI115505, anticorps AI427544, anticorps Acvrlk1, anticorps Alk1, anticorps activin A receptor like type 1, anticorps activin A receptor type II-like 1, anticorps activin A receptor, type II-like 1, anticorps ACVRL1, anticorps acvrl1, anticorps Acvrl1
Sujet
ACVRL1 is a type I cell-surface receptor for the TGF-beta superfamily of ligands. It shares with other type I receptors a high degree of similarity in serine-threonine kinase subdomains, a glycine- and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail. This protein, sometimes termed ALK1, shares similar domain structures with other closely related ALK or activin receptor-like kinase proteins that form a subfamily of receptor serine/threonine kinases. Mutations in this gene are associated with hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2.