PRKG2 anticorps (C-Term)

N° du produit ABIN392537

Détail du produit anti-PRKG2 anticorps

Antigène: PRKG2 (Protein Kinase, CGMP-Dependent, Type II (PRKG2))

Épitope: AA 714-744, C-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PRKG2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This cGKII antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 714-744 amino acids from the C-terminal region of human cGKII.

Clone: RB01036

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000. IHC-P: 1:50~100. IHC-P: 1:50~100

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 6 months

Références pour anticorps anti-PRKG2 (ABIN392537)

Zhu, Yao, Wu, Qian, Wu, Chen: "Type II cGMP-dependent protein kinase directly inhibits HER2 activation of gastric cancer cells." dans: Molecular medicine reports, Vol. 13, Issue 2, pp. 1909-13, (2016) (PubMed).

Yao, Wu, Zhu, Qian, Chen et al.: "Nitric oxide/cyclic guanosine monophosphate inducers sodium nitroprusside and L-arginine inhibit the proliferation of gastric cancer cells via the activation of type II cyclic guanosine ..." dans: Oncology letters, Vol. 10, Issue 1, pp. 479-484, (2015) (PubMed).

Jiang, Wu, Wu, Lan, Wang, Qian, Chen: "Type II cyclic guanosine monophosphate-dependent protein kinase inhibits epidermal growth factor receptor activation in different cancer cell lines." dans: Oncology letters, Vol. 9, Issue 6, pp. 2781-2786, (2015) (PubMed).

Rangaswami, Marathe, Zhuang, Chen, Yeh, Frangos, Boss, Pilz: "Type II cGMP-dependent protein kinase mediates osteoblast mechanotransduction." dans: The Journal of biological chemistry, Vol. 284, Issue 22, pp. 14796-808, (2009) (PubMed).

Détails sur PRKG2

Antigène: PRKG2 (Protein Kinase, CGMP-Dependent, Type II (PRKG2))

Autre désignation: cGKII (PRKG2 Produits)

Synonymes: anticorps MGC82580, anticorps PRKG2, anticorps si:dkey-18e17.2, anticorps PRKGR2, anticorps cGKII, anticorps GDPKII, anticorps AW212535, anticorps CGKII, anticorps Prkgr2, anticorps cGK-II, anticorps protein kinase, cGMP-dependent, type II, anticorps protein kinase, cGMP-dependent, type II L homeolog, anticorps cGMP-dependent protein kinase 2, anticorps PRKG2, anticorps prkg2.L, anticorps prkg2, anticorps LOC100541294, anticorps Prkg2

Sujet: CGKII is thought to play a key role in a diverse set of physiological pathway. cGKII may mediate intestinal secretion of water and electrolytes induced by the E. coli toxin STa and the intestinal peptide guanylin. Edentification of the pathway that mediates intestinal fluid secretion by E. coli STa has potential medical implications because STa causes traveler's diarrhea and about 50 % of infant mortality in developing countries. Transfection experiments in human cells disclose that cGKII phosphorylates SOX9 and attenuates SOX9 function by inhibiting its nuclear entry. Impaired differentiation of cultured KMI chondrocytes can be restored by silencing Sox9 by RNA interference. cGKII is postulated to be a molecular switch that couples the cessation of proliferation and the start of hypertrophic chondrocyte differentiation through attenuating SOX9 function.

Poids moléculaire: 87432

ID gène: 5593

NCBI Accession: NP_006250

UniProt: Q13237