NEK9 anticorps (C-Term)

N° du produit ABIN392654

Détail du produit anti-NEK9 anticorps

Antigène: NEK9 (NIMA (Never in Mitosis Gene A)- Related Kinase 9 (NEK9))

Épitope: AA 846-877, C-Term

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NEK9 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This NEK9 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 846-877 amino acids from the C-terminal region of human NEK9.

Clone: RB2989

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000. IHC-P: 1:50~100

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 6 months

Détails sur NEK9

Antigène: NEK9 (NIMA (Never in Mitosis Gene A)- Related Kinase 9 (NEK9))

Autre désignation: NEK9 (NEK9 Produits)

Synonymes: anticorps NERCC, anticorps NERCC1, anticorps Nek8, anticorps NEK9, anticorps nercc, anticorps nercc1, anticorps C130021H08Rik, anticorps NIMA related kinase 9, anticorps NIMA-related kinase 9, anticorps NIMA related kinase 8, anticorps NIMA (never in mitosis gene a)-related expressed kinase 9, anticorps NIMA-related kinase 9 L homeolog, anticorps NEK9, anticorps nek9, anticorps NEK8, anticorps Nek9, anticorps nek9.L

Sujet: NEK9, a member of the NIMA subfamily of Ser/Thr protein kinases, is a pleiotropic regulator of mitotic progression, participating in the control of spindle dynamics and chromosome separation. It phosphorylates different histones (serine and threonine residues on H3), myelin basic protein, beta-casein (serine residues), and BICD2. NEK9 is activated during mitosis by intramolecular autophosphorylation. Activity and autophosphorylation is activated by manganese >> magnesium ions, and is sensitive to increasing concentration of detergents. This protein is not cell-cycle regulated but activity is higher in G0-arrested cells. NEK is part of a homodimer that binds to Ran GTPase, and exhibits a greater affinity for Ran-GDP over Ran-GTP. Interaction is also noted with NEK6 and NEK7 family members. This cytoplasmic protein is most abundant in heart, liver, kidney and testis, and is also expressed in smooth muscle cells and fibroblasts. Expression varies mildly across the cell cycle, with highest expression observed in G1 and stationary-phase cells.

Poids moléculaire: 107168

ID gène: 91754

NCBI Accession: NP_149107

UniProt: Q8TD19

Pathways: SARS-CoV-2 Protein Interactome, Phosphorylation & l'infection par le SRAS-CoV-2