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PACSIN2 anticorps (C-Term)

PACSIN2 Reactivité: Humain, Souris WB, IHC (p) Hôte: Lapin Polyclonal RB3584 unconjugated
N° du produit ABIN392666
  • Antigène Voir toutes PACSIN2 Anticorps
    PACSIN2 (Protein Kinase C and Casein Kinase Substrate in Neurons 2 (PACSIN2))
    Épitope
    • 9
    • 6
    • 5
    • 3
    • 3
    • 2
    • 1
    • 1
    AA 342-371, C-Term
    Reactivité
    • 42
    • 17
    • 2
    Humain, Souris
    Hôte
    • 36
    • 6
    Lapin
    Clonalité
    • 38
    • 4
    Polyclonal
    Conjugué
    • 23
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp PACSIN2 est non-conjugé
    Application
    • 32
    • 20
    • 19
    • 10
    • 5
    • 5
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Purification
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogène
    This PACSIN2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 342-371 amino acids from the C-terminal region of human PACSIN2.
    Clone
    RB3584
    Isotype
    Ig Fraction
    Top Product
    Discover our top product PACSIN2 Anticorps primaire
  • Indications d'application
    WB: 1:1000. IHC-P: 1:25. IHC-P: 1:50~100
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Date de péremption
    6 months
  • Copeland, Han, Tiwari, Austin, Loyd, West, Kenworthy: "A disease-associated frameshift mutation in caveolin-1 disrupts caveolae formation and function through introduction of a de novo ER retention signal." dans: Molecular biology of the cell, Vol. 28, Issue 22, pp. 3095-3111, (2018) (PubMed).

    Han, Copeland, Kawano, Rosenzweig, Austin, Shahmirzadi, Tang, Raghunathan, Chung, Kenworthy: "Characterization of a caveolin-1 mutation associated with both pulmonary arterial hypertension and congenital generalized lipodystrophy." dans: Traffic (Copenhagen, Denmark), Vol. 17, Issue 12, pp. 1297-1312, (2017) (PubMed).

    Chandrasekaran, Kenworthy, Lacy: "Clostridium difficile Toxin A Undergoes Clathrin-Independent, PACSIN2-Dependent Endocytosis." dans: PLoS pathogens, Vol. 12, Issue 12, pp. e1006070, (2017) (PubMed).

    Bhattacharyya, Rainey, Arya, Mohapatra, Mushtaq, Dutta, George, Storck, McComb, Muirhead, Todd, Gould, Datta, Gelineau-van Waes, Band, Band: "Endocytic recycling protein EHD1 regulates primary cilia morphogenesis and SHH signaling during neural tube development." dans: Scientific reports, Vol. 6, pp. 20727, (2016) (PubMed).

    Bahl, Xie, Spagnol, Sorgen, Naslavsky, Caplan et al.: "EHD3 Protein Is Required for Tubular Recycling Endosome Stabilization, and an Asparagine-Glutamic Acid Residue Pair within Its Eps15 Homology (EH) Domain Dictates Its Selective Binding to NPF ..." dans: The Journal of biological chemistry, Vol. 291, Issue 26, pp. 13465-78, (2016) (PubMed).

    Cai, Giridharan, Zhang, Saxena, Bahl, Schmidt, Sorgen, Guo, Naslavsky, Caplan: "Differential roles of C-terminal Eps15 homology domain proteins as vesiculators and tubulators of recycling endosomes." dans: The Journal of biological chemistry, Vol. 288, Issue 42, pp. 30172-80, (2013) (PubMed).

    Giridharan, Cai, Vitale, Naslavsky, Caplan: "Cooperation of MICAL-L1, syndapin2, and phosphatidic acid in tubular recycling endosome biogenesis." dans: Molecular biology of the cell, Vol. 24, Issue 11, pp. 1776-90, S1-15, (2013) (PubMed).

    de Kreuk, Anthony, Geerts, Hordijk: "The F-BAR protein PACSIN2 regulates epidermal growth factor receptor internalization." dans: The Journal of biological chemistry, Vol. 287, Issue 52, pp. 43438-53, (2012) (PubMed).

    Hansen, Howard, Nichols: "Pacsin 2 is recruited to caveolae and functions in caveolar biogenesis." dans: Journal of cell science, Vol. 124, Issue Pt 16, pp. 2777-85, (2011) (PubMed).

    de Kreuk, Nethe, Fernandez-Borja, Anthony, Hensbergen, Deelder, Plomann, Hordijk: "The F-BAR domain protein PACSIN2 associates with Rac1 and regulates cell spreading and migration." dans: Journal of cell science, Vol. 124, Issue Pt 14, pp. 2375-88, (2011) (PubMed).

  • Antigène
    PACSIN2 (Protein Kinase C and Casein Kinase Substrate in Neurons 2 (PACSIN2))
    Autre désignation
    PACSIN2 (PACSIN2 Produits)
    Synonymes
    anticorps zgc:77519, anticorps PACSIN2, anticorps DKFZp459J1025, anticorps SDPII, anticorps AI197433, anticorps sdpii, anticorps SdpII, anticorps protein kinase C and casein kinase substrate in neurons 2, anticorps protein kinase C and casein kinase substrate in neurons 2 S homeolog, anticorps pacsin2, anticorps PACSIN2, anticorps Pacsin2, anticorps pacsin2.S
    Sujet
    PACSIN may play a role in vesicle formation and transport. This protein homo- and hetero-aggregates with other PACSINs. It also binds dynamin 1, synaptojanin, synapsin 1 and the neural Wiskott-Aldrich syndrome protein (N-WASP). The protein exhibits a cvesicle-like cytoplasmic distribution and is ubiquitously expressed. PACSIN is phosphorylated by casein kinase 2 (CK2) and protein kinase C (PKC). The protein contains 1 FCH domain and 1 SH3 domain.
    Poids moléculaire
    55739
    ID gène
    11252
    NCBI Accession
    NP_001171899, NP_001171900, NP_009160
    UniProt
    Q9UNF0
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