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SET Domain, Bifurcated 2 (SETDB2) (AA 620-720) anticorps

Détails pour le produit réf. ABIN393380, Fournisseur: Connectez-vous pour afficher Nouveau
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Antigène
Synonymes C13orf4, CLLD8, CLLL8, KMT1F, Clld8, Gm293
Épitope
AA 620-720
(31), (6), (3), (3), (1), (1), (1), (1), (1), (1)
Reactivité
Humain
(62), (19), (16), (6), (5), (5), (1)
Hôte
Souris
(29), (23), (10)
Clonalité (Clone)
Monoclonal ()
Conjugué
Inconjugué
(3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Transfer Western (WB)
(49), (35), (11), (3), (2), (2), (2), (2), (1)
Pubmed 5 références disponible
Fournisseur Connectez-vous pour afficher Nouveau
Numéro du produit fournisseur Connectez-vous pour afficher Nouveau
Quantité 0.05 mg
Options
Destination France ( )
Disponibilité Envoi sous 12 à 16 jours ouvrables
Immunogène SETDB2 (NP_114121, 620 a.a. ~ 720 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 1E2
Isotype IgG2a kappa
Specificité SETDB2 (NP_114121, 620 a.a. ~ 720 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification Purified
Autre désignation SETDB2 (SETDB2 Antibody Extrait)
Sujet Proteins that contain a SET domain, such as SETDB2, modulate gene expression epigenetically through histone H3 (see MIM 601128) methylation. SETDB2 is likely a histone H3 methyltransferase, as it contains both the active site and flanking cysteine residues required for catalytic activity (Zhang et al., 2003 [PubMed 12754510]).
Synonyms: C13orf4, CLLD8, CLLL8, DKFZp586I0123, DKFZp761J1217 SET domain, bifurcated 2
Poids moléculaire 81894 DA
ID gène 83852
NCBI Accession NP_114121
Domaine de recherche Signaling, Protein Modifications, Chromatin, Cell Structure
Indications d'application Western blot = 1:500-1000
Commentaires

Background: Proteins that contain a SET domain, such as SETDB2, modulate gene expression epigenetically through histone H3 (see MIM 601128) methylation. SETDB2 is likely a histone H3 methyltransferase, as it contains both the active site and flanking cysteine residues required for catalytic activity (Zhang et al., 2003 [PubMed 12754510]).

Restrictions For Research Use only
Buffer Phosphate buffered saline, pH 7.2
Stock 4 °C/-20 °C
Stockage commentaire Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Date de péremption 6 months
Supplier Images
Transfer Western (WB) image for anti-SET Domain, Bifurcated 2 (SETDB2) (AA 620-720) anticorps (ABIN393380) SETDB2 monoclonal antibody (M07), clone 1E2. Western Blot analysis of SETDB2 expressi...
Reference: Background Falandry, Fourel, Galy et al.: "CLLD8/KMT1F is a lysine methyltransferase that is important for chromosome segregation." dans: The Journal of biological chemistry, Vol. 285, Issue 26, pp. 20234-41, 2010 (PubMed).

Genuneit, Cantelmo, Weinmayr et al.: "A multi-centre study of candidate genes for wheeze and allergy: the International Study of Asthma and Allergies in Childhood Phase 2." dans: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, Vol. 39, Issue 12, pp. 1875-88, 2010 (PubMed).

Kimura, Wakamatsu, Suzuki et al.: "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. ..." dans: Genome research, Vol. 16, Issue 1, pp. 55-65, 2006 (PubMed).

Gerhard, Wagner, Feingold et al.: "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). ..." dans: Genome research, Vol. 14, Issue 10B, pp. 2121-7, 2004 (PubMed).

Dunham, Matthews, Burton et al.: "The DNA sequence and analysis of human chromosome 13. ..." dans: Nature, Vol. 428, Issue 6982, pp. 522-8, 2004 (PubMed).

N° du produit ABIN393380
454,76 €
Plus frais de livraison 40,00 € et TVA

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