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PARK7/DJ1 anticorps (AA 177-189)

PARK7 Reactivité: Humain, Singe, Poisson zèbre (Danio rerio), Chimpanzé WB, IHC (p), EIA Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN401278
  • Antigène Voir toutes PARK7/DJ1 (PARK7) Anticorps
    PARK7/DJ1 (PARK7) (Parkinson Protein 7 (PARK7))
    Épitope
    • 21
    • 16
    • 11
    • 7
    • 5
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 177-189
    Reactivité
    • 94
    • 71
    • 51
    • 8
    • 5
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain, Singe, Poisson zèbre (Danio rerio), Chimpanzé
    Hôte
    • 100
    • 15
    • 2
    • 1
    Lapin
    Clonalité
    • 94
    • 24
    Polyclonal
    Conjugué
    • 72
    • 13
    • 9
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp PARK7/DJ1 est non-conjugé
    Application
    • 96
    • 44
    • 31
    • 30
    • 27
    • 21
    • 20
    • 15
    • 14
    • 13
    • 5
    • 5
    • 5
    • 4
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Specificité
    Thisa ntibody is specific for PARK7.
    Réactivité croisée (Details)
    Species reactivity (expected):Chimpanzee, African green monkey, zebrafish and mutant/variant forms of human DJ-1 protein (100 %).. Cross reactivity with frog, mouse, rat, dog, chicken, Japanese rice fish and Atlantic salmon may also cross react as the sequence varies by only one amino acid residue as indicated by BLAST analysis.
    Species reactivity (tested):Human.
    Purification
    Immunoaffinity chromatography
    Immunogène
    Synthetic peptide corresponding aa 177-189 of Human PARK7 protein
    Isotype
    IgG
    Top Product
    Discover our top product PARK7 Anticorps primaire
  • Indications d'application
    ELISA: 1: 10,000 - 1: 50,000. Immunohistochemistry on paraffin sections: 2 μg/mL - 5 μg/mL. Western blot: 1: 500 - 1: 2,000 (Expect a band approximately 28 kDa in size correspondingto PARK7 in the appropriate cell lysate or extract).
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    1.3 mg/mL (by UV absorbance at 280 nm)
    Buffer
    0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2, 0.01 % (w/v) Sodium Azide
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freezing and thawing. Should this product contain a precipitate we recommend microcentrifugation before use.
    Stock
    4 °C/-20 °C
    Stockage commentaire
    Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer.
  • Antigène
    PARK7/DJ1 (PARK7) (Parkinson Protein 7 (PARK7))
    Autre désignation
    DJ-1 / PARK7 (PARK7 Produits)
    Synonymes
    anticorps DJ-1, anticorps DJ1, anticorps CAP1, anticorps Dj1, anticorps SP22, anticorps dj1, anticorps zgc:103725, anticorps park7b, anticorps park7, anticorps park7a, anticorps Parkinsonism associated deglycase, anticorps Parkinson disease (autosomal recessive, early onset) 7, anticorps parkinson protein 7, anticorps parkinson protein 7 S homeolog, anticorps parkinson protein 7 L homeolog, anticorps PARK7, anticorps Park7, anticorps park7, anticorps park7.S, anticorps park7.L
    Sujet
    The product of the PARK7 gene, known as PARK7, Parkinson disease (autosomal recessive, early onset) 7, DJ-1 mutant, and DJ-1 oncogene product, functions as a positive regulator of androgen receptor-dependent transcription. PARK7 may also function as a redoxsensitive chaperone and as a sensor for oxidative stress and also has been reported to prevent aggregation of SNCA. PARK7 protects neurons against oxidative stress and cell death and plays a role in fertilization. While PARK7 has no proteolytic activity, it does have a weak transforming activity. PARK7 forms a homodimer and binds to DJBP and PIAS2. PARK7 is part of a ternary complex containing PARK7, DJBP and AR and shows both a nuclear and cytoplasmic localization. In some cells, PARK7 is associated with mitochondria, particularly after oxidative stress. This protein is highly expressed in pancreas, kidney, skeletal muscle, liver, testis and heart tissue, and is expressed at lower levels in placenta and brain. PARK7 is detected in tau inclusions in brains from neurodegenerative disease patients, in astrocytes, Sertoli cells, spermatogonia, spermatids and spermatozoa. Defects in PARK7 are the cause of autosomal recessive early-onset Parkinson's disease 7 (PARK7). Parkinson's disease (PD) is a complex, multifactorial disorder that is characterized by bradykinesia, resting tremor, muscular rigidity and postural instability, response to treatment with levodopa, the loss of dopaminergic neurons in the substantia nigra and the presence of Lewy bodies (intraneuronal accumulations of aggregated proteins) in surviving neurons.Synonyms: Oncogene DJ1, Parkinson disease protein 7
    ID gène
    11315
    NCBI Accession
    NP_001116849
    UniProt
    Q99497
    Pathways
    Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Proton Transport
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