AHSA1 anticorps (Internal Region)

N° du produit ABIN401377

Détail du produit anti-AHSA1 anticorps

Antigène: AHSA1 (Activator of HSP90 ATPase Activity 1 (AHSA1))

Épitope: Internal Region

Reactivité: Humain, Chimpanzé

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp AHSA1 est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificité: This antibody is directed against AHA1 protein.

Réactivité croisée (Details): Species reactivity (expected):Chimpanzee.
Species reactivity (tested):Human.

Purification: Affinity chromatography

Immunogène: Synthetic peptide corresponding to an internal region of human AHA1 protein

Isotype: IgG

Information d'application

Indications d'application: ELISA: 1/35,000 - 1/185,000. Western Blot: 1/500 - 1/3,000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.08 mg/mL (by UV absorbance at 280 nm)

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 containing 0.01 % (w/v) Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Détails sur AHSA1

Antigène: AHSA1 (Activator of HSP90 ATPase Activity 1 (AHSA1))

Autre désignation: AHA1 / AHSA1 (AHSA1 Produits)

Synonymes: anticorps ahsa1, anticorps MGC52884, anticorps MGC132147, anticorps MGC80312, anticorps AHSA1, anticorps MGC89589, anticorps wu:fb83b05, anticorps zgc:136821, anticorps zgc:56075, anticorps AHA1, anticorps C14orf3, anticorps p38, anticorps BC023857, anticorps AHA1, activator of heat shock 90kDa protein ATPase homolog 1 S homeolog, anticorps activator of Hsp90 ATPase activity 1, anticorps AHA1, activator of heat shock 90kDa protein ATPase homolog 1 L homeolog, anticorps activator of HSP90 ATPase activity 1, anticorps AHA1, activator of heat shock 90kDa protein ATPase homolog 1, anticorps AHA1, activator of heat shock protein ATPase homolog 1a, anticorps AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast), anticorps AHA1, activator of heat shock protein ATPase 1, anticorps ahsa1.S, anticorps AHSA1, anticorps ahsa1.L, anticorps ahsa1, anticorps ahsa1a, anticorps Ahsa1

Sujet: Activator of Hsp90 ATPase (AHA1) stimulates the inherent ATPase cycle of Hsp90, which is essential for its chaperone activity in vivo. The activation and/or stability of many of the key regulatory and signaling proteins of the eukaryotic cell depend on their interaction with the Hsp90 Molecular chaperone. Hsp90 is assisted and regulated by co-chaperones that participate in an ordered series both to assist clientprotein recruitment or release and to modulate progress through the ATPase coupled chaperone cycle. Structural analysis and mutagenesis show that binding of the N-terminal domain of AHA1 to Hsp90 promotes a conformational switch in the middle-segment catalytic loop (aa 370-390) of Hsp90 that exposes the catalytic Arg380 and enables its interaction with ATP in the N-terminal nucleotide-binding domain of the chaperone. Recent studies show that AHA1 modulates Hsp90-dependent stability of the folding of the cystic fibrosis transmembrane conductance regulator (CFTR) in the endoplasmic reticulum (ER). Down-regulation of AHA1 rescues misfolding of CFTR in cystic fibrosis.Synonyms: Activator of 90 kDa heat shock protein ATPase homolog 1, C14orf3, HSPC322

ID gène: 10598

NCBI Accession: NP_036243

UniProt: O95433