NCOA3 anticorps (Internal Region, Isoform A)

N° du produit ABIN401408

Détail du produit anti-NCOA3 anticorps

Antigène: NCOA3 (Nuclear Receptor Coactivator 3 (NCOA3))

Épitope: Internal Region, Isoform A

Reactivité: Humain, Singe

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NCOA3 est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificité: This antibody reacts with several isoforms of NCOA3 protein (a, b, d, e and f).

Réactivité croisée (Details): Species reactivity (expected):Marcaque, Canine, Bovine, Mouse, Rat.
Species reactivity (tested):Human.

Purification: Affinity chromatography

Immunogène: Synthetic peptide corresponding to an internal region of human NCOA3 isoform a protein

Isotype: IgG

Information d'application

Indications d'application: ELISA: 1/175000. Western Blot: 1/500 - 1/1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.24 mg/mL (by UV absorbance at 280 nm)

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 containing 0.01 % (w/v) Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Détails sur NCOA3

Antigène: NCOA3 (Nuclear Receptor Coactivator 3 (NCOA3))

Autre désignation: NCOA3 (NCOA3 Produits)

Synonymes: anticorps NCOA3, anticorps ACTR, anticorps AIB-1, anticorps AIB1, anticorps CAGH16, anticorps CTG26, anticorps KAT13B, anticorps RAC3, anticorps SRC-3, anticorps SRC3, anticorps TNRC14, anticorps TNRC16, anticorps TRAM-1, anticorps bHLHe42, anticorps pCIP, anticorps 2010305B15Rik, anticorps AW321064, anticorps Actr, anticorps Aib1, anticorps Rac3, anticorps Src3, anticorps Tram-1, anticorps Tram1, anticorps p/Cip, anticorps pCip, anticorps actr, anticorps aib-1, anticorps aib1, anticorps cagh16, anticorps ctg26, anticorps kat13b, anticorps pcip, anticorps rac3, anticorps src-3, anticorps src3, anticorps tnrc14, anticorps tnrc16, anticorps tram-1, anticorps xSRC-3, anticorps nuclear receptor coactivator 3, anticorps nuclear receptor coactivator 3 S homeolog, anticorps NCOA3, anticorps Ncoa3, anticorps ncoa3.S

Sujet: The NCOA3 (also known as nuclear receptor coactivator 3 isoform a) is a nuclear receptor coactivator that interacts with nuclear hormone receptors to enhance their transcriptional activator functions in a hormone-dependent fashion. The encoded protein has histone acetyltransferase activity and recruits p300/CBP-associated factor and CREB binding protein as part of a multisubunit coactivation complex. NCOA3 probably acts via remodeling of chromatin and is involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). NCOA3 is also involved in the coactivation of the NF-kappa-B pathway via its interaction with the NFKB1 subunit. This protein is initially found in the cytoplasm but is translocated into the nucleus upon phosphorylation. Two transcript variants encoding different isoforms have been found for this gene. This antibody was raised against variant 1 which is the longer isoform (a). In addition, a polymorphic repeat region is found in the C-terminus of the protein.Synonyms: ACTR, AIB-1, AIB1, Amplified in breast cancer 1 protein, BHLHE42, CBP-interacting protein, Class E basic helix-loop-helix protein 42, NCoA-3, Nuclear receptor coactivator 3, RAC-3, RAC3, Receptor-associated coactivator 3, SRC-3, Steroid receptor coactivator protein 3, TRAM-1, TRAM1, Thyroid hormone receptor activator molecule 1, pCIP

ID gène: 8202

NCBI Accession: NP_001167559

UniProt: Q9Y6Q9

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Regulation of Lipid Metabolism by PPARalpha